Azithromycin Capsules 250mg / High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: capsule
• Packing: Customization
• Package: 6 Capsules / Box
• Transport Package: Box
• Specification: 250mg
• Trademark: Sinolead
• Origin: China

Product Description

Azithromycin Capsules 250mg

Composition:

Each capsule contains:

• Azithromycin (as Azithromycin Dihydrate) .........… 250mg
• Excipients .........… (as required)

Description:

Azithromycin is a broad-spectrum macrolide antibiotic that works by inhibiting bacterial protein synthesis. It is effective against a variety of Gram-positive, Gram-negative, and atypical bacteria.

Indications:

Azithromycin Capsules are indicated for the treatment of infections caused by susceptible organisms, including:

• Respiratory tract infections (e.g., pneumonia, bronchitis, pharyngitis, sinusitis)
• Skin and soft tissue infections
• Ear infections (acute otitis media)
• Sexually transmitted infections (e.g., chlamydia, gonorrhea)
• Helicobacter pylori-associated peptic ulcer disease (as part of combination therapy)

Dosage & Administration:

Adults & Adolescents (≥12 years):

• Standard dose: 500mg once daily for 3 days OR 500mg on Day 1, then 250mg once daily on Days 2-5
• Chlamydia trachomatis infections: Single dose of 1g (1000mg) once
• H. pylori eradication (as part of combination therapy): 500mg once daily for 3 days

Children (Under 12 years):

• Dose is weight-based: 10mg/kg/day for 3 days
• Alternative regimen: 10mg/kg on Day 1, then 5mg/kg on Days 2-5

Administration Instructions:

• Take 1 hour before or 2 hours after meals (food may reduce absorption).
• Swallow whole with water; do not crush or chew.

Contraindications:

• Hypersensitivity to Azithromycin, macrolide, or ketolide antibiotics
• Severe liver dysfunction
• History of cholestatic jaundice or hepatic dysfunction with prior Azithromycin use

Precautions:

• Use with caution in patients with liver or kidney impairment
• Monitor for QT prolongation, especially in patients with heart disease or taking other QT-prolonging drugs
• Avoid use in severe myasthenia gravis (may worsen symptoms)
• May cause Clostridioides difficile-associated diarrhea (CDAD)

Adverse Reactions:

• Common: Nausea, vomiting, diarrhea, abdominal pain, headache
• Serious: QT prolongation, arrhythmia, hepatotoxicity, severe allergic reactions (e.g., anaphylaxis, Stevens-Johnson Syndrome)

Drug Interactions:

• Increased risk of QT prolongation with antipsychotics, quinolones, and antiarrhythmic drugs
• May reduce effectiveness of live bacterial vaccines
• Increases the levels of warfarin, digoxin, cyclosporine - monitor closely
• Avoid simultaneous use with aluminum- or magnesium-containing antacids (may reduce absorption)

Overdose & Management:

• Symptoms: Severe nausea, vomiting, diarrhea, liver toxicity, hearing loss
• Treatment: Supportive care, symptomatic treatment (e.g., IV fluids, antiemetics)

Storage Conditions:

• Store at 20-25°C, protect from moisture and light
• Keep out of reach of children