Sodium Valproate Concentrated Solution for Injection 500mg/5ml / High Quality

• Customization: Available
• Packaging From: 1 Vial /Box
• Packaging: Customization
• Model NO.: Powder for injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 500mg/5ml
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
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Sodium Valproate Concentrated Solution for Injection 500mg/5ml

Composition:

Each 5mL ampoule contains:

• Sodium Valproate 500mg

Description:

Sodium Valproate is an antiepileptic drug (AED) used for the treatment of epilepsy, seizures, and bipolar disorder. It works by increasing the availability of gamma-aminobutyric acid (GABA), a neurotransmitter that stabilizes nerve activity.

Indications:

Sodium Valproate Injection is indicated for:

• Epilepsy (generalized & focal seizures)
• Acute manic episodes in bipolar disorder
• Prophylaxis of migraine (in certain cases, if oral therapy is not feasible)

Dosage & Administration:

Intravenous (IV) Use Only

• Can be given as a slow IV injection (over 3-5 minutes) or IV infusion (over 30-60 minutes).
• Transition to oral therapy as soon as feasible.

Adult Dosage:

• Epilepsy: 400-800mg IV per day (max 30mg/kg/day)
• Acute seizures (status epilepticus): Initial 15-20mg/kg IV bolus, followed by infusion 1-3mg/kg/hr

Pediatric Dosage:

• Children >20kg: 10-15mg/kg/day, max 30mg/kg/day
• Children <20kg: 20mg/kg/day, divided into 2-3 doses

Reconstitution & Administration:

• Dilution (for infusion): Dilute with normal saline (0.9% NaCl) or 5% dextrose
• Administer slowly to avoid CNS depression & cardiovascular effects

Contraindications:

• Hypersensitivity to Sodium Valproate
• Severe liver dysfunction
• Urea cycle disorders

Precautions:

• Monitor liver function (risk of hepatotoxicity, especially in children <2 years)
• Use with caution in renal impairment
• Risk of teratogenicity (avoid in pregnancy unless necessary)

Adverse Reactions:

• Common: Nausea, dizziness, tremors, drowsiness
• Serious: Hepatotoxicity, pancreatitis, thrombocytopenia, hyperammonemia

Drug Interactions:

• Increased effect with phenytoin, carbamazepine
• Increased sedation with benzodiazepines
• Avoid alcohol & CNS depressants

Overdose & Management:

• Symptoms: Respiratory depression, hypotension, metabolic acidosis
• Treatment: Supportive care, hemodialysis if needed

Storage Conditions:

• Store below 25°C, protect from light
• Use reconstituted solution within 24 hours (if refrigerated at 2-8°C)