Celecoxib Capsules 200mg / High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: capsule
• Packing: Customization
• Package: 20 Capsules / Box
• Transport Package: Box
• Specification: 200mg
• Trademark: Sinolead
• Origin: China

Product Description

Celecoxib Capsules 200mg

Composition:

Each capsule contains:

• Celecoxib 200mg

Description:

Celecoxib is a selective COX-2 inhibitor, classified as a nonsteroidal anti-inflammatory drug (NSAID). It provides anti-inflammatory, analgesic, and antipyretic effects with a lower risk of gastrointestinal complications compared to non-selective NSAIDs.

Indications:

Celecoxib is indicated for the treatment of:

• Osteoarthritis (OA)
• Rheumatoid arthritis (RA)
• Ankylosing spondylitis
• Acute pain (e.g., postoperative, musculoskeletal pain)
• Primary dysmenorrhea (menstrual pain)

Dosage & Administration:

Adults:

• Osteoarthritis: 200mg once daily or 100mg twice daily
• Rheumatoid arthritis: 100-200mg twice daily
• Ankylosing spondylitis: 200mg once daily or 100mg twice daily
• Acute pain & Dysmenorrhea: Initial dose 400mg, followed by 200mg if needed on the first day, then 200mg twice daily as needed

Elderly Patients (≥65 years):

• No dosage adjustment needed, but lower doses should be considered in patients with low body weight (<50kg)

Patients with Hepatic Impairment:

• Moderate impairment (Child-Pugh Class B): Reduce dose by 50%
• Severe impairment: Use is not recommended

Patients with Renal Impairment:

• Use with caution in patients with severe renal disease (CrCl <30 mL/min)

Administration:

• Can be taken with or without food
• Swallow capsules whole with water
• For patients who have difficulty swallowing, the capsule contents may be mixed with applesauce

Contraindications:

• Hypersensitivity to Celecoxib, sulfonamides, or other NSAIDs
• History of severe allergic reactions (e.g., anaphylaxis, angioedema) to NSAIDs
• Active peptic ulcer disease or gastrointestinal bleeding
• Severe hepatic or renal impairment
• Coronary artery bypass graft (CABG) surgery-increased risk of cardiovascular events

Precautions:

• Cardiovascular Risk: May increase the risk of heart attack, stroke, and hypertension, especially with long-term use
• Gastrointestinal Risk: May cause gastric ulcers, bleeding, or perforation, especially in elderly patients
• Renal Effects: May cause fluid retention, hypertension, and kidney dysfunction-monitor renal function
• Use in Pregnancy: Avoid in the third trimester-may cause fetal harm

Adverse Reactions:

• Common: Nausea, dyspepsia, diarrhea, headache, dizziness, peripheral edema
• Serious: Hypertension, heart failure, gastrointestinal bleeding, renal dysfunction, Stevens-Johnson syndrome

Drug Interactions:

• Anticoagulants (Warfarin, Heparin): Increased bleeding risk-monitor INR closely
• Diuretics & ACE Inhibitors: May reduce effectiveness-monitor blood pressure and kidney function
• Other NSAIDs & Corticosteroids: Increased risk of gastrointestinal bleeding
• Fluconazole: May increase Celecoxib levels-consider dose reduction

Storage Conditions:

• Store below 25°C, in a dry place
• Protect from light and moisture