Voglibose Tablets 0.2mg / High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: Tablet
• Packing: Customization
• Package: 30 Tablets /Box
• Transport Package: Box
• Specification: 0.2mg
• Trademark: Sinolead
• Origin: China
• Production Capacity: 10, 000, 000

Product Description

Amlodipine Besylate and Atorvastatin Calcium Tablets 2.5mg/10mg

Composition:

Each tablet contains:

• Amlodipine Besylate equivalent to Amlodipine 2.5mg
• Atorvastatin Calcium equivalent to Atorvastatin 10mg

Description:

Amlodipine is a calcium channel blocker (CCB) that relaxes blood vessels and improves blood flow, helping to lower blood pressure.
Atorvastatin is a statin (HMG-CoA reductase inhibitor) that reduces cholesterol levels and lowers the risk of cardiovascular diseases.

Indications:

This combination is used for the management of hypertension, angina, and dyslipidemia, particularly in patients requiring both blood pressure control and lipid-lowering therapy. It is indicated for:

• Hypertension (high blood pressure)
• Chronic stable angina and vasospastic angina
• Hypercholesterolemia and mixed dyslipidemia
• Prevention of cardiovascular events in high-risk patients

Dosage & Administration:

Adults:

• Usual dose: 1 tablet once daily, with or without food
• Dose adjustment: Based on clinical response
• Maximum dose: Amlodipine 10mg/day, Atorvastatin 80mg/day

Renal Impairment:

• No dose adjustment required.

Hepatic Impairment:

• Use with caution; contraindicated in active liver disease.

Contraindications:

• Hypersensitivity to Amlodipine, Atorvastatin, or excipients
• Active liver disease or unexplained persistent elevations in liver enzymes
• Pregnancy and breastfeeding
• Concomitant use with strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole)

Precautions:

• Liver Function: Monitor liver enzymes before and during treatment.
• Muscle Toxicity: Risk of myopathy, rhabdomyolysis; discontinue if muscle pain or weakness occurs.
• Hypotension Risk: Caution in patients with severe aortic stenosis.
• CYP3A4 Interactions: Avoid grapefruit juice and certain medications that increase Atorvastatin levels.

Adverse Reactions:

• Common: Headache, dizziness, peripheral edema, flushing, fatigue
• Gastrointestinal: Nausea, abdominal pain, constipation
• Musculoskeletal: Myalgia, muscle cramps
• Hepatic: Elevated liver enzymes (rare)
• Serious (rare): Rhabdomyolysis, acute renal failure, severe hypotension

Drug Interactions:

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): Increased Atorvastatin levels
• Grapefruit juice: May increase the risk of muscle toxicity
• Digoxin: Amlodipine may increase digoxin levels
• Antihypertensive agents: Increased blood pressure-lowering effects
• Warfarin: Atorvastatin may slightly enhance anticoagulant effects

Storage Conditions:

• Store below 25°C, in a dry place, away from light.
• Keep out of reach of children.