Irbesartan and Hydrochlorothiazide Tablets 150mg+12.5mg/High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: Tablet
• Packing: Customization
• Package: 30 Tablets /Box
• Transport Package: Box
• Specification: 150mg+12.5mg
• Trademark: Sinolead
• Origin: China

Product Description

Irbesartan and Hydrochlorothiazide Tablets (150mg/12.5mg)

Composition:

Each tablet contains:

• Irbesartan 150mg (Angiotensin II Receptor Blocker - ARB)
• Hydrochlorothiazide (HCTZ) 12.5mg (Thiazide Diuretic)

Description:

This fixed-dose combination consists of Irbesartan, an angiotensin II receptor blocker (ARB) that relaxes blood vessels, and Hydrochlorothiazide (HCTZ), a diuretic that helps eliminate excess salt and water from the body. The combination effectively lowers high blood pressure (hypertension) and reduces cardiovascular risks.

Indications:

Irbesartan and Hydrochlorothiazide Tablets are indicated for:

• Hypertension in patients not adequately controlled on Irbesartan or HCTZ monotherapy
• Patients requiring combination therapy for better blood pressure control

Dosage & Administration:

Adults:

• Starting dose: 150mg/12.5mg once daily
• Maintenance dose: 150mg/12.5mg or 300mg/12.5mg once daily
• Maximum dose: 300mg/25mg per day

Renal Impairment:

• Not recommended for patients with severe kidney disease (eGFR <30 mL/min/1.73m²)

Hepatic Impairment:

• Use with caution in moderate liver disease
• Not recommended in severe hepatic impairment

Elderly Patients:

• No dosage adjustment required, but monitor kidney function closely

Administration:

• Take once daily, preferably in the morning
• Can be taken with or without food
• Do not crush or chew

Contraindications:

• Hypersensitivity to Irbesartan, HCTZ, or excipients
• Pregnancy (Category D) - fetal toxicity risk
• Severe kidney or liver disease
• Anuria (inability to produce urine)
• Severe electrolyte imbalance (e.g., hypokalemia, hypercalcemia)

Precautions:

• Monitor blood pressure, kidney function, and electrolyte levels regularly
• Risk of dehydration and hypotension due to diuretic effect
• Hyperkalemia risk with potassium supplements or potassium-sparing diuretics
• Increased photosensitivity (use sunscreen when exposed to sunlight)
• Diabetic patients: May cause blood sugar fluctuations
• Gout patients: HCTZ may increase uric acid levels

Adverse Reactions:

• Common: Dizziness, headache, fatigue, muscle cramps, nausea
• Electrolyte Imbalance: Hypokalemia, hyponatremia, hypercalcemia
• Cardiovascular: Hypotension, palpitations
• Serious (rare): Angioedema, severe hypotension, kidney dysfunction

Drug Interactions:

• NSAIDs: May reduce antihypertensive effect and worsen kidney function
• Potassium-sparing diuretics (e.g., spironolactone): Risk of hyperkalemia
• Lithium: Increased risk of lithium toxicity
• Other antihypertensives: May enhance blood pressure-lowering effects
• Antidiabetic drugs: HCTZ may reduce effectiveness of insulin or oral hypoglycemics

Storage Conditions:

• Store below 25°C, in a dry place, away from light.
• Keep out of reach of children.