Atorvastatin Calcium Tablets 20mg / High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: Tablet
• Packing: Customization
• Package: 10 Tablets /Box
• Transport Package: Box
• Specification: 20mg
• Trademark: Sinolead
• Origin: China

Product Description

Atorvastatin Calcium Tablets 20mg

Composition:

Each tablet contains:

• Atorvastatin Calcium equivalent to Atorvastatin 20mg

Description:

Atorvastatin is a statin (HMG-CoA reductase inhibitor) that lowers cholesterol and triglyceride levels in the blood, reducing the risk of cardiovascular diseases such as heart attack and stroke.

Indications:

Atorvastatin Calcium Tablets are indicated for:

• Hypercholesterolemia (High cholesterol, including familial and non-familial)
• Mixed dyslipidemia (High cholesterol and triglycerides)
• Prevention of cardiovascular diseases in high-risk patients
• Reduction of stroke and heart attack risk in diabetic or hypertensive patients

Dosage & Administration:

Adults & Adolescents (≥10 years):

• Usual dose: 10mg to 80mg once daily, based on lipid levels
• Starting dose: 10-20mg once daily
• Maximum dose: 80mg per day
• Administered with or without food

Pediatric Use (10-17 years, familial hypercholesterolemia):

• Starting dose: 10mg once daily
• Maximum dose: 20mg per day

Renal Impairment:

• No dosage adjustment required.

Hepatic Impairment:

• Contraindicated in active liver disease
• Use with caution in patients with a history of liver disease.

Contraindications:

• Hypersensitivity to Atorvastatin or excipients
• Active liver disease or unexplained persistent liver enzyme elevations
• Pregnancy and breastfeeding
• Concomitant use with strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole)

Precautions:

• Liver Function: Monitor liver enzymes before and during treatment.
• Muscle Toxicity: Risk of myopathy and rhabdomyolysis; discontinue if muscle pain or weakness occurs.
• Diabetes Risk: May slightly increase blood sugar levels.
• CYP3A4 Interactions: Avoid grapefruit juice and certain medications that increase Atorvastatin levels.

Adverse Reactions:

• Common: Headache, nausea, diarrhea, constipation, muscle pain
• Serious (rare): Rhabdomyolysis, liver dysfunction, hypersensitivity reactions
• Other: Fatigue, dizziness, elevated liver enzymes

Drug Interactions:

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): Increased Atorvastatin levels
• Grapefruit juice: May increase the risk of muscle toxicity
• Anticoagulants (e.g., warfarin): May enhance anticoagulant effects
• Fibrates (e.g., gemfibrozil): Increased risk of myopathy

Storage Conditions:

• Store below 25°C, in a dry place, away from light.
• Keep out of reach of children.