Levofloxacin Hydrochloride and Sodium Chloride Injection / High Quality

• Customization: Available
• Packing: Customization
• Materials: PP Bottle
• Model NO.: injection
• Transport Package: Carton
• Specification: 100ml
• Trademark: Sinolead
• Origin: China

Product Description

Value-added services:
 Packaging design by our team
 Registration service by our team
 Registration dossier available by our team
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Levofloxacin Hydrochloride and Sodium Chloride Injection

Product Overview

Levofloxacin Hydrochloride and Sodium Chloride Injection is a sterile, non-pyrogenic solution designed for intravenous administration. It contains Levofloxacin Hydrochloride, a broad-spectrum fluoroquinolone antibiotic, in 0.9% Sodium Chloride solution. This ready-to-use formulation is effective against a wide range of bacterial infections.

Key Features

• Active Ingredient: Levofloxacin Hydrochloride

• Concentration: Commonly available as 500mg/100ml or 750mg/150ml.

• Formulation: Clear, slightly yellow to yellow solution.

• Administration: Intravenous infusion.

• Packaging: Single-dose bags or bottles, typically in 100ml or 150ml sizes.

Indications

• Bacterial Infections: Treatment of adults with infections caused by susceptible strains of bacteria, including:

  • Community-acquired pneumonia (CAP).

  • Hospital-acquired pneumonia (HAP).

  • Acute bacterial sinusitis (ABS).

  • Complicated skin and skin structure infections (cSSSI).

  • Complicated urinary tract infections (cUTI).

  • Acute pyelonephritis.

• Broad-Spectrum Activity: Effective against Gram-positive, Gram-negative, and atypical pathogens.

Mechanism of Action

• Levofloxacin is a third-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for DNA replication, transcription, and repair.

• This action leads to bacterial cell death and prevents further growth of susceptible organisms.

Dosage and Administration

• Recommended Dosage:

  • Adults:

    • 500mg (100ml) once daily for mild to moderate infections.

    • 750mg (150ml) once daily for severe or complicated infections.

  • Duration of Treatment: Typically 7-14 days, depending on the type and severity of the infection.

• Administration:

  • Must be administered as a slow intravenous infusion over 60-90 minutes.

  • Can be switched to oral levofloxacin (same dosage) once the patient's condition improves.

• Compatibility: Can be infused with other compatible intravenous fluids if needed.

Advantages

• Broad-Spectrum Coverage: Effective against a wide range of bacterial pathogens.

• Once-Daily Dosing: Convenient dosing regimen improves patient compliance.

• Ready-to-Use Formulation: Eliminates the need for reconstitution, reducing preparation time and risk of errors.

Storage and Handling

• Storage: Store at controlled room temperature (15-30°C). Protect from light and freezing.

• Shelf Life: Typically 24-36 months, depending on the manufacturer.

Precautions

• Contraindicated in patients with known hypersensitivity to levofloxacin, other fluoroquinolones, or any component of the formulation.

• Use with caution in patients with:

  • Prolonged QT interval or risk of arrhythmias.

  • Tendon disorders or risk of tendon rupture.

  • Central nervous system disorders (e.g., epilepsy).

• Avoid use in pregnant or lactating women unless absolutely necessary.

Adverse Effects

• Common side effects include nausea, diarrhea, headache, and dizziness.

• Rare but serious side effects may include:

  • Tendon rupture.

  • Peripheral neuropathy.

  • QT prolongation and arrhythmias.

  • Severe hypersensitivity reactions.