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Amoxicillin Sodium and Clavulanate Potassium for Injection
Each vial contains:
Amoxicillin Sodium: Equivalent to 500mg, 1000mg, or 2000mg of Amoxicillin.
Clavulanate Potassium: Equivalent to 100mg, 200mg, or 400mg of Clavulanic Acid.
Amoxicillin Sodium and Clavulanate Potassium for Injection is a combination antibiotic medication. Amoxicillin is a penicillin-class antibiotic that fights bacteria, while clavulanate potassium is a beta-lactamase inhibitor that prevents bacterial resistance. This combination enhances the effectiveness of the treatment against a broader range of bacteria. The injectable form is suitable for severe infections or when oral administration is not feasible.
This medication is used to treat infections caused by susceptible strains of bacteria, including:
Severe respiratory tract infections (e.g., pneumonia, empyema)
Complicated urinary tract infections (e.g., pyelonephritis)
Intra-abdominal infections (e.g., peritonitis)
Skin and soft tissue infections (e.g., cellulitis, abscesses)
Bone and joint infections (e.g., osteomyelitis)
Septicemia
Adults and children ≥40kg:
500mg/100mg or 1000mg/200mg: 1 vial every 8 hours, intravenously.
2000mg/400mg: 1 vial every 12 hours, intravenously.
Children <40kg:
Dosage: 25-45mg/kg body weight per day (based on amoxicillin component), divided into 2-3 doses.
Administration: Reconstitute the vial with sterile water for injection or compatible IV fluids. Administer by slow intravenous injection or infusion over 30-40 minutes.
Common side effects may include:
Gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea)
Allergic reactions (e.g., rash, itching)
Injection site reactions (e.g., pain, redness)
Serious side effects (e.g., severe diarrhea, hepatotoxicity, anaphylaxis) are rare but require immediate medical attention.
Hypersensitivity to penicillin, cephalosporins, or any component of the formulation.
History of cholestatic jaundice or liver dysfunction associated with this medication.
Consult a doctor before use if you have a history of kidney disease, liver disease, or mononucleosis.
Regular monitoring of liver and kidney function is recommended during prolonged use.
Not effective against viral infections (e.g., colds, flu).
Probenecid: May increase amoxicillin blood levels.
Oral contraceptives: May reduce contraceptive efficacy.
Methotrexate: May increase the risk of methotrexate toxicity.
Other antibiotics: May cause antagonistic effects.
Before reconstitution: Store in a cool, dry place (below 25°C), away from direct sunlight.
After reconstitution: Use immediately or store in the refrigerator (2-8°C) for up to 24 hours. Do not freeze.
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