Cloxacillin for Injection 500mg / High Quality

• Customization: Available
• Packaging From: 10 Vials /Box
• Packaging: Customization
• Model NO.: Powder for injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 500mg
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------

 

Cloxacillin for Injection 500mg

Composition:

Each vial contains:

• Cloxacillin Sodium - 500mg (equivalent to 500mg Cloxacillin)

Description:

Cloxacillin is a semisynthetic penicillin with a narrow-spectrum antibacterial activity. It is resistant to β-lactamase enzymes produced by Staphylococcus aureus, making it effective against penicillin-resistant staphylococcal infections.

Indications:

Used for the treatment of infections caused by penicillinase-producing staphylococci, including:

• Skin & soft tissue infections (boils, abscesses, cellulitis, impetigo)
• Respiratory tract infections (pneumonia, bronchitis, pharyngitis, tonsillitis)
• Bone & joint infections (osteomyelitis, septic arthritis)
• Endocarditis
• Septicemia

Dosage & Administration:

Intravenous (IV) or Intramuscular (IM) Use

• Adults & children >12 years: 500mg every 6 hours
• Severe infections: 1g every 4-6 hours
• Maximum dose: 8g per day
• Children (under 12 years): 50-100mg/kg/day in divided doses every 6 hours

Reconstitution & Administration:

• IV injection: Dissolve 500mg vial in 10mL sterile water, administer slowly over 3-5 minutes
• IM injection: Dissolve 500mg vial in 2mL sterile water, inject deep intramuscularly

Contraindications:

• Hypersensitivity to cloxacillin, penicillins, or cephalosporins
• History of severe allergic reactions (anaphylaxis, angioedema)

Precautions:

• Use with caution in patients with renal or hepatic impairment
• May cause Clostridium difficile-associated diarrhea (CDAD)
• Cross-allergenicity with other β-lactam antibiotics (e.g., cephalosporins)

Adverse Reactions:

• Common: Nausea, vomiting, diarrhea, skin rash
• Serious: Anaphylaxis, severe skin reactions (Stevens-Johnson syndrome), liver dysfunction

Drug Interactions:

• Probenecid: Increases cloxacillin levels
• Oral contraceptives: May reduce contraceptive effectiveness
• Methotrexate: Increased toxicity risk

Overdose & Management:

• Symptoms: Nausea, vomiting, diarrhea, seizures (in severe cases)
• Treatment: Supportive care, IV fluids, hemodialysis if necessary

Storage Conditions:

• Store below 25°C, protect from light and moisture
• Use reconstituted solution immediately