Ondansetron Hydrochloride Suppositories USP 4mg / High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: Suppositories
• Packing: Customization
• Package: 5 Suppositories / Box
• Transport Package: Box
• Specification: 4mg
• Trademark: Sinolead
• Origin: China

Product Description

Ondansetron Hydrochloride Suppositories USP 4mg

Composition:

Each suppository contains:

• Ondansetron Hydrochloride (equivalent to Ondansetron 4mg)

Description:

Ondansetron Hydrochloride is a selective 5-HT3 receptor antagonist used to prevent and treat nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. The suppository formulation provides an alternative non-oral route of administration for patients unable to take oral medication.

Indications:

Ondansetron Hydrochloride Suppositories are indicated for the prevention and treatment of:

• Chemotherapy-induced nausea and vomiting (CINV)
• Radiation therapy-induced nausea and vomiting (RINV)
• Postoperative nausea and vomiting (PONV)

Dosage & Administration:

Adults & Children (>12 years):

• One suppository (4mg) inserted rectally every 8-12 hours as needed.

Children (4-11 years):

• One suppository (4mg) inserted rectally every 12 hours.

Administration:

• For rectal use only.
• Wash hands before and after use.
• Insert gently into the rectum.
• Avoid excessive movement for a few minutes after insertion.

Contraindications:

• Hypersensitivity to Ondansetron or other 5-HT3 antagonists.
• Patients with severe hepatic impairment (dose adjustment required).

Warnings & Precautions:

• Serotonin syndrome risk when used with serotonergic drugs (e.g., SSRIs, SNRIs).
• QT prolongation risk, especially in patients with heart conditions.
• Use with caution in patients with liver disease.
• May cause constipation in some patients.

Adverse Reactions:

• Common: Headache, dizziness, fatigue, constipation
• Serious: Arrhythmias, serotonin syndrome, severe allergic reactions

Drug Interactions:

• Apomorphine: Severe hypotension risk
• Serotonergic drugs (SSRIs, SNRIs): Increased risk of serotonin syndrome
• CYP3A4 inducers (e.g., rifampin): May reduce Ondansetron efficacy

Storage Conditions:

• Store below 25°C (77°F)
• Protect from heat and moisture