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| Generic Name | Felodipine Extended-Release Tablets 5mg |
| Strength | 5mg |
| Packing | 10tabs/blister,3blisters/box |
| Origin | China |
This product is a film coating, after removing the film coating white or white.
Hypertension, stable angina pectoris.
Usage and dosage:
Oral, dosage should be individualized.
The pill should be swallowed in the morning with water. The pill should not be broken, crushed or chewed.
1. Treatment of hypertension:
A starting dose of 5 mg once a day is recommended, and a maintenance dose of 5 or 10 mg once a day is commonly used. Depending on the patient's response, the dose can be further reduced or increased, or other antihypertensive drugs can be added. The dose adjustment interval is usually not less than 2 weeks. For some patients, such as elderly patients and those with liver impairment, 2.5mg once a day may be sufficient. Doses over 10mg once a day are usually not required.
2. Treatment of angina:
A starting dose of 5 mg once a day is recommended, and a maintenance dose of 5 or 10 mg once a day is commonly used.
Renal impairment
The serum concentration of felodipine was not affected by renal function impairment. No dose adjustment is required. Patients with severe renal impairment should use this product with caution.
Matters needing attention:
Aortic stenosis, liver damage, and severe renal impairment (GFR< 30 mL/min), with caution for heart failure after acute myocardial infarction.
Boyetin contains lactose. It should be contraindicated in patients with the following rare genetic disorders: galactose intolerance, lactase deficiency, glucose-galactose malabsorption.
Concurrent administration of CYP 3A4 inducer can dramatically reduce felodipine blood levels and has the risk of causing loss of felodipine effect, and this combination should be avoided.
Concomitant administration of drugs that may inhibit CYP 3A4 can lead to a significant increase in felodipine blood levels, and this combination should be avoided.
Ingestion of grapefruit juice at the same time can cause a significant increase in felodipine blood levels, and this combination should be avoided.
Similar to other vasodilators, felodipine may cause significant hypotension in a very small number of patients, which may cause myocardial ischemia in susceptible individuals, and should be used with caution in patients with hypotension.
Clinical trials have shown that doses greater than 10 mg per day can increase the antihypertensive effect, but at the same time increase the incidence of peripheral edema and other vasodilation adverse events.
In patients with hepatic impairment, plasma clearance of felodipine decreases and blood concentration increases, so a starting dose of 2.5 mg once a day is recommended. These patients should monitor their blood pressure carefully while adjusting the dose.
Patients with renal insufficiency generally do not need to adjust the recommended dose.
Women who are trying to become pregnant should discontinue use.
This product should be taken orally on an empty stomach or a small amount of light diet, should be swallowed whole tablets do not bite or chew. Maintaining good oral hygiene can reduce the incidence and severity of gum growth.
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