Omeprazole Sodium Capsules 40mg / High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: capsule
• Packing: Customization
• Package: 2*7 Capsules / Box
• Transport Package: Box
• Specification: 20mg; 40mg
• Trademark: Sinolead
• Origin: China

Product Description

Omeprazole Sodium Capsules

Composition:

Each capsule contains:

• Omeprazole Sodium, equivalent to Omeprazole (20mg, or 40mg depending on the strength)

Description:

Omeprazole is a proton pump inhibitor (PPI) that suppresses gastric acid secretion by inhibiting the H+/K+-ATPase enzyme system in the gastric parietal cells. It is used to treat acid-related gastrointestinal disorders.

Indications:

Omeprazole Sodium Capsules are indicated for:

• Gastroesophageal Reflux Disease (GERD)
• Erosive Esophagitis
• Peptic Ulcer Disease (gastric and duodenal ulcers)
• Helicobacter pylori eradication (in combination with antibiotics)
• Zollinger-Ellison Syndrome and other hypersecretory conditions
• Non-steroidal anti-inflammatory drug (NSAID)-induced ulcers prevention

Dosage & Administration:

Recommended Dosage for Adults:

• GERD & Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks
• Peptic Ulcer Disease:
  • Duodenal Ulcer: 20 mg once daily for 4 weeks
  • Gastric Ulcer: 40 mg once daily for 4-8 weeks
• H. pylori Eradication (Triple Therapy):
  • Omeprazole 20 mg twice daily + Clarithromycin 500 mg twice daily + Amoxicillin 1 g twice daily for 10-14 days
• Zollinger-Ellison Syndrome: 60 mg once daily, adjusted as needed
• NSAID-induced Ulcer Prevention: 20 mg once daily

Pediatric Dosage:

• GERD (Children ≥1 year & ≥10 kg): 10-20 mg once daily
• Erosive Esophagitis (Children ≥1 year & ≥20 kg): 20-40 mg once daily

Administration:

• Take before meals, preferably in the morning
• Swallow the capsule whole with water
• If difficulty swallowing, open the capsule and mix the granules with a small amount of applesauce (do not crush or chew the granules)

Dose Adjustments:

• Hepatic Impairment: Maximum 20 mg/day in severe liver disease
• Renal Impairment & Elderly: No dosage adjustment required

Contraindications:

• Hypersensitivity to Omeprazole or other PPIs
• Coadministration with atazanavir or rilpivirine

Precautions:

• Long-term use may increase the risk of:
  • Clostridium difficile-associated diarrhea
  • Osteoporosis-related fractures
  • Vitamin B12 deficiency
  • Hypomagnesemia
• Evaluate patients with persistent symptoms for gastric malignancy

Adverse Reactions:

• Common: Headache, nausea, diarrhea, abdominal pain, constipation
• Serious: Hypomagnesemia, interstitial nephritis, Clostridium difficile infection

Drug Interactions:

• Warfarin: Increased bleeding risk-monitor INR
• Methotrexate: May increase methotrexate toxicity
• Clopidogrel: May reduce antiplatelet effect-use alternative PPI if necessary

Overdose & Management:

• Symptoms: Dizziness, confusion, tachycardia
• Treatment: Supportive care (no specific antidote)

Storage Conditions:

• Store below 25°C, protect from moisture and light