Value-added services:
1) Packaging design by our team
2) Registration service by our team
3) Registration dossier available by our team
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Cefoperazone Sodium and Sulbactam Sodium for Injection 1g
Composition:
Each vial contains:
- Cefoperazone Sodium 500mg
- Sulbactam Sodium 500mg
Description:
Cefoperazone Sodium and Sulbactam Sodium for Injection is a combination of a third-generation cephalosporin (Cefoperazone) and a β-lactamase inhibitor (Sulbactam). This combination enhances the antibacterial activity of Cefoperazone by preventing bacterial resistance caused by β-lactamase enzymes.
Indications:
This injection is used for the treatment of infections caused by susceptible organisms, including:
- Respiratory tract infections (pneumonia, bronchitis, lung abscess)
- Urinary tract infections
- Intra-abdominal infections (peritonitis, cholangitis, cholecystitis)
- Sepsis and bacteremia
- Gynecological infections (endometritis, pelvic inflammatory disease)
- Skin and soft tissue infections
- Bone and joint infections
Dosage & Administration:
- Adults:
- The usual dose is 1-2 g every 12 hours, administered via intravenous (IV) or intramuscular (IM) injection.
- In severe infections, the dosage may be increased to 4 g per day in divided doses.
- Children:
- The recommended dose is 40-80 mg/kg/day in two divided doses.
- Renal Impairment:
- Dosage adjustments may be necessary in patients with severe renal dysfunction.
Administration:
- Intravenous (IV) Infusion: Dissolve the contents of the vial in sterile water for injection and administer over 15-30 minutes.
- Intramuscular (IM) Injection: Dissolve the vial contents in an appropriate volume of lidocaine solution (if applicable, per physician's recommendation) or sterile water.
Contraindications:
- Patients with a history of severe allergic reactions to cephalosporins or penicillins.
- Use with caution in patients with hepatic dysfunction.
Precautions:
- A skin sensitivity test is recommended before administration, especially in allergic patients.
- Use with caution in patients with renal or liver impairment, as dosage adjustments may be required.
- Monitor for possible gastrointestinal side effects, such as diarrhea or pseudomembranous colitis.
Adverse Reactions:
- Gastrointestinal: Nausea, vomiting, diarrhea, abdominal pain.
- Allergic Reactions: Rash, itching, anaphylaxis (rare).
- Hepatic: Elevated liver enzymes (ALT, AST).
- Hematologic: Changes in white blood cell count, prolonged prothrombin time.
Drug Interactions:
- Concurrent use with aminoglycosides may increase nephrotoxicity risk.
- Prolonged use with anticoagulants may increase bleeding tendencies.
- Alcohol consumption should be avoided, as it may cause a disulfiram-like reaction (flushing, nausea, palpitations).
Storage Conditions:
- Store below 25°C, protect from light and moisture.
- Keep out of reach of children.
){kind=link}