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| Generic Name | Cefotaxime Sodium for Injection 500mg |
| Strength | 500mg |
| Packing | 1 vial+1 Ampoule/Box |
| Origin | China |
This product is white to yellowish white crystalline powder.
It is suitable for pneumonia and other lower respiratory tract infection, urinary tract infection, meningitis, septicemia, abdominal infection, pelvic infection, skin soft tissue infection, reproductive tract infection, bone and joint infection caused by sensitive bacteria. Cefotaxime can be used as the drug of choice in children with meningitis.
Usage and dosage:
For adults, 2 ~ 6g a day, divided into 2 ~ 3 times intravenous injection or intravenous drip; Severely infected people are 2 to 3g every 6 to 8 hours, and the maximum daily dose is not more than 12g. Treatment for uncomplicated Streptococcus pneumoniae pneumonia or acute urinary tract infection, 1g every 12 hours.
For newborns less than 7 days old, 50mg/kg every 12 hours, and for newborns greater than 7 days old, 50mg/kg every 8 hours. In patients with meningitis, the dose can be increased to 75mg/kg every 6 hours, all administered intravenously.
Patients with severe renal dysfunction should be appropriately reduced when using this product. When the serum creatinine value exceeds 424μmol/L(4.8mg) or the creatinine clearance is less than 20ml/, the maintenance dose of this product should be halved. When serum creatinine exceeds 751μmol/L(8.5mg), the maintenance amount is 1/4 of the normal amount. Hemodialysis patients need 0.5 ~ 2g a day. However, one dose should be added after dialysis.
Matters needing attention:
(1) An allergy test should be performed before medication.
(2) Cross-allergic reaction: People who are allergic to one cephalosporin or cephalosporin may also be allergic to other cephalosporins or cephalosporin. People who are allergic to penicillin or penicillamine may also be allergic to this product.
(3) Interference with diagnosis: the antiglobulin (Coombs) test of patients using this product can be positive; Prenatal use of this product in pregnant women, this reaction can appear in newborns. The determination of urine sugar by copper sulfate method can be false positive. Serum alkaline phosphatase, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase or serum lactate dehydrogenase values can be increased.
(4) Cefotaxime sodium 1.05g is equivalent to 1g cefotaxime, and the sodium content per 1g of cefotaxime sodium is about 2.2mmol(51mg). 1g cefotaxime was dissolved in 14ml sterilized water for injection to form an isotonic solution.
(5) When preparing intramuscular injection, 0.5g, 1.0g or 2.0g of cefotaxime was added to 2ml, 3ml or 5ml of sterile water for injection, respectively. For intravenous injection, add at least 10 to 20ml of sterilized water for injection into the above different amounts of cefotaxime and inject slowly within 5 to 10 minutes. For intravenous infusion, dilute the intravenous injection with an appropriate solvent to 100 ~ 500ml. When the intramuscular injection dose exceeds 2g, the injection should be divided into different sites.
(6) Patients with renal dysfunction should be used with caution when the dose is reduced; Use with caution in patients with gastrointestinal diseases or renal dysfunction.
(7) This product and aminoglycoside can not be injected in the same bottle
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