Ondansetron Injection USP 8mg/4ml / High Quality

• Customization: Available
• Packaging From: 5 Ampoules/Box
• Packaging: Customization
• Model NO.: injection
• Dosage: Ready
• Transport Package: Shipping
• Specification: 4ml: 8mg
• Trademark: brand
• Origin: China

Product Description

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Ondansetron Injection USP 8mg/4mL (2 mg/mL)

Composition:

Each 4mL ampoule contains:

• Ondansetron (as hydrochloride dihydrate) - 8 mg (2 mg/mL)
• Excipients: Sodium chloride, Citric acid monohydrate, Sodium citrate, Water for injection

Description:

Ondansetron is a selective 5-HT3 receptor antagonist that prevents nausea and vomiting caused by chemotherapy, radiation therapy, and surgery. It works by blocking serotonin in the central nervous system and gastrointestinal tract.

Indications:

Ondansetron Injection is indicated for:

• Prevention & treatment of chemotherapy-induced nausea and vomiting (CINV)
• Prevention of postoperative nausea and vomiting (PONV)
• Prevention of nausea & vomiting due to radiation therapy

Dosage & Administration:

Adults

• Chemotherapy-induced nausea & vomiting (CINV):
  • High emetogenic chemotherapy: 8 mg IV over 15 minutes, 30 minutes before chemotherapy
  • Moderate emetogenic chemotherapy: 8 mg IV over 15 minutes, followed by 8 mg every 8 hours for 1-2 days
• Postoperative nausea & vomiting (PONV):
  • Prevention: 4 mg IV as a single dose before anesthesia
  • Treatment: 4 mg IV as a single dose

Pediatrics (≥6 months old)

• CINV: 0.15 mg/kg IV every 4-8 hours (max 8 mg per dose)
• PONV: 0.1 mg/kg IV (max 4 mg per dose) before surgery

Administration:

• Slow IV injection over 2-5 minutes
• IV infusion: Dilute in 50 mL of 0.9% NaCl or 5% Dextrose and infuse over 15 minutes

Contraindications:

• Hypersensitivity to ondansetron or other 5-HT3 antagonists
• Congenital long QT syndrome

Precautions:

• QT prolongation risk: Caution in patients with cardiac disorders
• Electrolyte imbalances (hypokalemia, hypomagnesemia) may increase risk of arrhythmias
• Use with caution in liver impairment (max dose 8 mg/day in severe hepatic impairment)
• Monitor for serotonin syndrome if used with serotonergic drugs

Adverse Reactions:

• Common: Headache, dizziness, constipation, fatigue
• Serious: QT prolongation, arrhythmia, serotonin syndrome

Drug Interactions:

• Apomorphine: Increased risk of severe hypotension and loss of consciousness (contraindicated)
• Serotonergic drugs (SSRIs, SNRIs, tramadol): Increased risk of serotonin syndrome
• QT-prolonging drugs (Amiodarone, Haloperidol): Increased risk of arrhythmias

Overdose & Management:

• Symptoms: Visual disturbances, hypotension, arrhythmias
• Treatment: Symptomatic management, ECG monitoring

Storage Conditions:

• Store below 30°C
• Protect from light
• Do not freeze