Piperacillin Sodium and Sulbactam Sodium for Injection 1.5g / High Quality

• Customization: Available
• Packaging From: 10 Vials /Box
• Packaging: Customization
• Model NO.: Powder for injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 1.5 g
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
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Piperacillin Sodium and Sulbactam Sodium for Injection 1.5g

Composition:

Each vial contains:

• Piperacillin Sodium equivalent to Piperacillin 1g
• Sulbactam Sodium equivalent to Sulbactam 0.5g

Description:

Piperacillin is a broad-spectrum penicillin antibiotic that acts against Gram-positive, Gram-negative, and anaerobic bacteria. Sulbactam is a beta-lactamase inhibitor that protects piperacillin from degradation by bacterial beta-lactamases, thereby enhancing its antibacterial activity.

Indications:

Piperacillin/Sulbactam for Injection is indicated for the treatment of serious infections caused by susceptible bacteria, including:

• Respiratory tract infections (e.g., pneumonia, bronchitis)
• Complicated intra-abdominal infections (e.g., peritonitis, abscesses)
• Complicated urinary tract infections (UTIs)
• Complicated skin and soft tissue infections
• Gynecological infections (e.g., pelvic inflammatory disease, endometritis)
• Septicemia and bacteremia

Dosage & Administration:

Adults & Adolescents (≥12 years):

• Usual dose: 1.5g IV every 8 hours
• Severe infections: 3g IV every 6-8 hours

Pediatric Patients (2 months - 12 years):

• 100 mg/kg/day (piperacillin/sulbactam) divided every 8 hours
• Severe infections: 300 mg/kg/day divided every 6-8 hours

Neonates (<2 months):

• 75 mg/kg IV every 12 hours

Renal Impairment (Adults & Adolescents):

Creatinine Clearance (CrCl)	Dose	Dosing Interval
≥40 mL/min	Usual dose	Every 6-8 hours
20-40 mL/min	1.5g IV	Every 12 hours
<20 mL/min	0.75g IV	Every 12 hours
Hemodialysis	0.75g IV after dialysis	Every 12 hours

Administration:

• Intravenous (IV) infusion over 30 minutes
• Intramuscular (IM) injection in deep muscle
• Dilute with 0.9% Sodium Chloride (NS) or 5% Dextrose (D5W)

Contraindications:

• Hypersensitivity to Piperacillin, Sulbactam, Penicillins, or Cephalosporins.

Precautions:

• Risk of allergic reactions - Monitor for anaphylaxis.
• Monitor renal function, especially in elderly patients.
• Hematologic effects: May cause thrombocytopenia or neutropenia.
• C. difficile-associated diarrhea - discontinue if severe diarrhea occurs.
• Sodium content - Use with caution in patients with heart failure or hypertension.

Adverse Reactions:

• Gastrointestinal: Diarrhea, nausea, vomiting.
• Hematologic: Neutropenia, thrombocytopenia, anemia.
• Renal: Increased creatinine, acute kidney injury (rare).
• Allergic Reactions: Rash, urticaria, anaphylaxis (rare).
• Injection Site Reactions: Phlebitis, pain.

Drug Interactions:

• Aminoglycosides: Should not be mixed in the same IV solution.
• Probenecid: Increases piperacillin levels.
• Anticoagulants (e.g., warfarin): May increase bleeding risk.
• Methotrexate: Reduced clearance may increase toxicity.
• Vancomycin: Increased nephrotoxicity risk.

Storage Conditions:

• Store below 25°C, protect from light.
• Reconstituted solution should be used within 24 hours if refrigerated (2-8°C) or immediately if stored at room temperature.