Gemcitabine Hydrochloride for Injection 1g / High Quality

• Customization: Available
• Packaging From: 1 Vial /Box
• Packaging: Customization
• Model NO.: Powder for injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 1g
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
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Gemcitabine Hydrochloride for Injection 1g

Composition:

Each vial contains:

• Gemcitabine Hydrochloride - 1g
• Excipients: None or specified buffering agents (if applicable)

Description:

Gemcitabine Hydrochloride is a nucleoside analog chemotherapy drug that inhibits DNA synthesis, leading to cell death in rapidly dividing tumor cells. It is used to treat various cancers, including non-small cell lung cancer (NSCLC), pancreatic cancer, breast cancer, ovarian cancer, and bladder cancer.

Indications:

• Non-Small Cell Lung Cancer (NSCLC) (alone or in combination with cisplatin)
• Pancreatic Cancer (first-line treatment for advanced/metastatic cases)
• Breast Cancer (in combination with paclitaxel for metastatic cases)
• Ovarian Cancer (with carboplatin for recurrent cases)
• Bladder Cancer (with cisplatin for locally advanced/metastatic cases)

Dosage & Administration:

Intravenous (IV) Infusion Only

• Standard dose: 1,000-1,250 mg/m² over 30 minutes, depending on cancer type
• Frequency: Once weekly or on specific days in a chemotherapy cycle
• Dilution: Reconstitute 1g vial with 25mL sterile saline (0.9% NaCl, non-preserved) to a concentration of 40mg/mL

Administration Guidelines:

• Do not administer as IV bolus (risk of increased toxicity)
• Monitor CBC counts before each dose
• Adjust dose in case of hematologic toxicity

Contraindications:

• Hypersensitivity to gemcitabine or any excipient
• Severe bone marrow suppression
• Pregnancy and lactation (unless benefits outweigh risks)

Precautions:

• Monitor blood cell counts regularly (risk of myelosuppression)
• Use with caution in patients with hepatic or renal impairment
• Avoid live vaccines during treatment
• Hydration recommended to prevent kidney toxicity

Adverse Reactions:

• Common: Fatigue, nausea, vomiting, fever, rash, anemia, leukopenia, thrombocytopenia
• Serious: Pulmonary toxicity, hepatotoxicity, renal toxicity, infusion reactions

Drug Interactions:

• Platinum-based chemotherapy (cisplatin, carboplatin): Increased hematologic toxicity
• Radiation therapy: Potential radiation recall syndrome
• Warfarin: Increased risk of bleeding (monitor INR closely)

Overdose & Management:

• Symptoms: Severe myelosuppression, liver/kidney dysfunction, bleeding
• Treatment: Supportive care, blood transfusions if needed, symptomatic management

Storage Conditions:

• Store at 15°C-30°C
• Reconstituted solution: Use immediately or within 24 hours if refrigerated
• Protect from light