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Oxytocin Injection 5 I.U./1mL
Composition:
Each 1mL ampoule contains:
- Oxytocin - 5 International Units (I.U.)
- Excipients: Sodium chloride, Acetic acid (for pH adjustment), Water for injection
Description:
Oxytocin is a synthetic hormone identical to the natural oxytocin produced by the posterior pituitary gland. It stimulates uterine contractions and is used in obstetric care.
Indications:
Oxytocin Injection is indicated for:
- Induction and augmentation of labor in cases of inadequate uterine contractions
- Management of postpartum hemorrhage (PPH) due to uterine atony
- Prevention of postpartum uterine bleeding
- Facilitation of incomplete or missed abortion (miscarriage management)
Dosage & Administration:
For Labor Induction/Augmentation:
- Intravenous (IV) infusion:
- Initial dose: 1-2 milliunits/min, increased gradually by 1-2 milliunits/min every 15-30 minutes
- Maximum dose: 20 milliunits/min
- Discontinue if hyperstimulation or fetal distress occurs
For Postpartum Hemorrhage (PPH) Prevention & Treatment:
- Intramuscular (IM): 5-10 I.U. after delivery of the placenta
- IV infusion: 10-40 I.U. diluted in 500-1000mL of saline or dextrose, infused at an appropriate rate
For Incomplete/Missed Abortion:
- IV infusion: 10 I.U. in 500mL normal saline or dextrose, infused at a rate of 20-40 drops per minute
Contraindications:
- Hypersensitivity to Oxytocin
- Hypertonic or hyperactive uterus
- Fetal distress when vaginal delivery is not imminent
- Obstructed labor (e.g., cephalopelvic disproportion, malpresentation)
- Uterine rupture risk (previous C-section, uterine surgery)
Precautions:
- Continuous fetal and maternal monitoring required during administration
- Avoid excessive doses to prevent uterine rupture or fetal distress
- Use cautiously in hypertensive patients or those with cardiovascular disease
Adverse Reactions:
- Maternal:
- Uterine hyperstimulation (tetanic contractions, rupture risk)
- Hypotension, tachycardia, nausea, vomiting
- Fluid retention (risk of water intoxication)
- Fetal:
- Bradycardia, distress, neonatal jaundice
Drug Interactions:
- Prostaglandins: Increased uterine effects (risk of hyperstimulation)
- Vasoconstrictors (e.g., epinephrine): May cause severe hypertension
- Anesthetic agents: May reduce oxytocin response
Overdose & Management:
- Symptoms: Uterine hyperstimulation, fetal distress, water intoxication
- Treatment: Discontinue oxytocin, administer supportive care (oxygen, fluids), consider tocolytic agents (e.g., terbutaline) if needed
Storage Conditions:
- Store at 2°C-8°C (Refrigerated)
- Do not freeze
- Protect from light


