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Moxifloxacin Hydrochloride and Sodium Chloride Injection 250ml: 0.4g
Composition:
Each 250ml contains:
- Moxifloxacin Hydrochloride equivalent to Moxifloxacin 0.4g (400mg)
- Sodium Chloride (sufficient quantity for isotonicity)
Description:
Moxifloxacin is a broad-spectrum fluoroquinolone antibiotic with activity against Gram-positive, Gram-negative, and atypical bacteria. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and bacterial growth. The sodium chloride component helps maintain electrolyte balance.
Indications:
Moxifloxacin Hydrochloride and Sodium Chloride Injection is indicated for the treatment of bacterial infections caused by susceptible organisms, including:
- Community-acquired pneumonia (CAP)
- Complicated skin and soft tissue infections
- Complicated intra-abdominal infections
- Acute bacterial sinusitis
- Acute exacerbation of chronic bronchitis
Dosage & Administration:
Adults (≥18 years):
- 400mg IV once daily (infused over 60 minutes)
- Duration:
- Pneumonia: 7-14 days
- Skin infections: 7-21 days
- Intra-abdominal infections: 5-14 days
Pediatric Use:
- Not recommended due to potential joint toxicity.
Renal Impairment:
- No dosage adjustment required.
Hepatic Impairment:
- Use with caution in patients with severe hepatic dysfunction.
Administration:
- Intravenous (IV) infusion only
- Infuse over 60 minutes
- Do NOT mix with other IV medications
- No further dilution required
Contraindications:
- Hypersensitivity to Moxifloxacin, other fluoroquinolones, or excipients
- Pregnant and breastfeeding women (unless necessary)
- Patients with myasthenia gravis due to risk of respiratory failure
Precautions:
- QT Prolongation: Avoid use in patients with known QT prolongation, uncorrected electrolyte imbalance, or those taking other QT-prolonging drugs.
- Tendon Rupture Risk: Increased risk, especially in elderly patients and those on corticosteroids.
- Peripheral Neuropathy: Discontinue if symptoms occur.
- Hypoglycemia/Hyperglycemia: Monitor blood glucose in diabetic patients.
- Clostridium difficile-Associated Diarrhea (CDAD): Consider discontinuation if severe diarrhea occurs.
Adverse Reactions:
- Cardiovascular: QT prolongation, tachycardia
- Neurologic: Dizziness, headache, insomnia, peripheral neuropathy
- Gastrointestinal: Nausea, diarrhea, abdominal pain
- Musculoskeletal: Tendinitis, tendon rupture (rare)
- Hepatic: Elevated liver enzymes
- Injection Site Reactions: Phlebitis, pain
Drug Interactions:
- QT-prolonging agents (e.g., amiodarone, quinidine): Increased risk of arrhythmia.
- NSAIDs: May increase the risk of CNS effects (e.g., seizures).
- Warfarin: May enhance anticoagulant effects.
- Antidiabetic drugs: Risk of blood glucose fluctuations.
Storage Conditions:
- Store below 25°C, protect from light.
- Do NOT freeze.
- Use immediately after opening.
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