| Customization: | Available |
|---|---|
| Dosage Form: | Powder Injection |
| Dossier: | Ready |
|
Still deciding? Get samples of US$ 0.1/Piece
Request Sample
|
Suppliers with verified business licenses
Audited Supplier Audited by an independent third-party inspection agency
| Generic Name | Gultathione Lyophilized Powder For Injection 600mg |
| Strength | 600mg |
| Packing | 10vials/box |
| Origin | China |
For the prevention and treatment of tissue and cell damage caused by drugs [such as chemotherapy drugs, anti-tuberculosis drugs, psychoneurotic drugs, paracetamol, etc.], radiation therapy, alcohol and organophosphorus; It has protective effect on liver injury caused by various reasons.
Pharmacological action:
Reduced glutathione is a tripeptide substance widely existing in nature. It is mainly found in the cytoplasm and plays a role in a variety of cellular biochemical functions. The sulfhydryl group of cysteine in reduced glutathione is highly nucleophilic and is therefore the primary target structure for electrophiles excited by heteroorganisms or their metabolites, thus providing protection against major nucleophilic sites, which if affected can lead to cell damage. Once reacted with organic oxidation metabolites, it can form low-toxicity compounds that are easily metabolized. The level of intracellular glutathione is altered and reduced in many cases such as malnutrition, various diseases, chemical poisoning and drug administration. In animals and humans, reduced glutathione has protective effects against cytotoxicity induced by many substances such as salicylic acid, organophosphorus insecticides and alcohol. In vivo studies in animals have shown that reduced glutathione does not affect intestinal motility, blood pressure and respiration, and does not cause ECG changes.
Toxicological study
Acute toxicity test: Slow intravenous infusion of glutathione sodium salt at 1000mg/kg did not cause death in rats and mice. Rabbits can tolerate a dose of 3000mg/kg. Intraperitoneally administered doses of 7,500 mg/kg did not cause death in rats and mice.
Repeated dose toxicity test: Glutathione sodium salt was administered intravenously at 500mg/kg/ day and 1000mg/kg/ day for 28 days without causing any pathological changes in rabbits. The administration of sodium glutathione intrabitoneally for 90 days at doses of 4386mg/kg/ day and 129mg/kg/ day did not cause any pathologically significant symptoms in rats, nor did it cause histological and biochemical abnormalities.
Teratogenicity experiments: Glutathione was administered to Wistar rats and New Zealand rabbits at a dose of 86mg/kg/ day without affecting reproduction, growth and lactation of newborn animals.
No special precautions. Keep out of reach of children.
Medication for special population:
Pregnant women should not use this product unless it can be shown that the benefits outweigh the risks to the fetus; It is not recommended for lactating women unless it is proven that the benefits outweigh the risks.
){kind=link}