Acyclovir for Injection 250mg / High Quality

• Customization: Available
• Packaging From: 10 Vials /Box
• Packaging: Customization
• Model NO.: Powder for injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 250mg
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
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Acyclovir for Injection 250mg

Composition:

Each vial contains:

• Acyclovir Sodium (equivalent to 250 mg of Acyclovir)

Description:

Acyclovir is a synthetic nucleoside analog antiviral drug that inhibits herpes simplex virus (HSV) DNA polymerase, preventing viral replication. It is effective against HSV-1, HSV-2, and Varicella-Zoster Virus (VZV) and is used for severe or systemic viral infections.

Indications:

Acyclovir for Injection is indicated for the treatment of:

• Severe herpes simplex virus (HSV) infections
• Herpes simplex encephalitis
• Neonatal herpes infections
• Varicella-Zoster Virus (VZV) infections, including herpes zoster (shingles) and severe chickenpox
• HSV or VZV infections in immunocompromised patients

Dosage & Administration:

Adults & Adolescents (≥12 years):

• Severe HSV infections: 5 mg/kg IV every 8 hours for 5-10 days
• HSV encephalitis: 10 mg/kg IV every 8 hours for 10-21 days
• Varicella-Zoster infections (shingles): 10 mg/kg IV every 8 hours for 7-10 days

Pediatric Patients:

• Neonatal herpes (≤28 days old): 20 mg/kg IV every 8 hours for 14-21 days
• Varicella in immunocompromised children: 10 mg/kg IV every 8 hours for 7-10 days

Renal Impairment:

• CrCl 25-50 mL/min: Administer every 12 hours
• CrCl 10-25 mL/min: Administer every 24 hours
• CrCl <10 mL/min: Administer half dose every 24 hours
• Hemodialysis: Give dose after dialysis

Administration Instructions:

• Reconstitution:
  • Add 10 mL of sterile water for injection to the 250 mg vial
  • Shake gently until fully dissolved
  • Further dilute in at least 50-100 mL of 0.9% NaCl or 5% dextrose before infusion
• IV Infusion:
  • Administer slowly over 1 hour to prevent kidney toxicity
  • Do not administer as IV bolus or rapid injection

Contraindications:

• Hypersensitivity to Acyclovir, Valacyclovir, or excipients
• Severe renal impairment (use with caution, dose adjustment required)

Precautions:

• Ensure adequate hydration to reduce the risk of kidney damage
• Monitor renal function in elderly or dehydrated patients
• Neurological side effects (agitation, confusion, seizures) may occur in high doses

Adverse Reactions:

• Common: Nausea, vomiting, headache, dizziness
• Serious: Acute kidney injury (crystalluria), neurotoxicity (hallucinations, seizures), phlebitis at the injection site

Drug Interactions:

• Probenecid: Reduces renal clearance of Acyclovir-monitor for toxicity
• Mycophenolate Mofetil: Increases Acyclovir levels-use with caution
• Ciclosporin & Tacrolimus: Increases nephrotoxicity risk-monitor renal function

Overdose & Management:

• Symptoms: Renal failure, confusion, seizures
• Treatment: Hydration, symptomatic care, hemodialysis if necessary

Storage Conditions:

• Store below 25°C, protect from light
• Use reconstituted solution within 12 hours