Ceftazidime and Avibactam Sodium for Injection 2.5g / High Quality

• Customization: Available
• Packaging From: 10 Vials /Box
• Packaging: Customization
• Model NO.: Powder for injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 2.5 g
• Trademark: Customization
• Origin: China

Product Description

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Ceftazidime and Avibactam Sodium for Injection 2.5g

Composition:

Each vial contains:

• Ceftazidime (as Ceftazidime Sodium) 2g
• Avibactam (as Avibactam Sodium) 0.5g

Description:

Ceftazidime is a third-generation cephalosporin antibiotic with broad-spectrum activity against Gram-negative bacteria, including Pseudomonas aeruginosa. Avibactam is a non-β-lactam β-lactamase inhibitor that enhances the activity of ceftazidime by inhibiting bacterial resistance mechanisms (β-lactamases). This combination is particularly effective against carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant (MDR) infections.

Indications:

Ceftazidime and Avibactam for Injection is indicated for the treatment of the following infections in adults and pediatric patients (≥3 months) caused by susceptible Gram-negative bacteria:

• Complicated intra-abdominal infections (cIAI) (in combination with metronidazole)
• Complicated urinary tract infections (cUTI), including pyelonephritis
• Hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP)
• Bacteremia associated with the above infections

Dosage & Administration:

• Adults and Adolescents (≥18 years):
  • 2.5g (2g ceftazidime + 0.5g avibactam) every 8 hours via intravenous (IV) infusion over 2 hours
  • Duration:
    • cIAI and cUTI: 5-14 days
    • HAP/VAP: 7-14 days
• Pediatric Patients (≥3 months - <18 years):
  • 50 mg/kg (maximum 2.5g per dose) every 8 hours via IV infusion over 2 hours
• Patients with Renal Impairment:
  • Dosage adjustment required based on creatinine clearance (CrCl ≤50 mL/min)

Administration:

• Intravenous (IV) Infusion:
  • Reconstitute with sterile water for injection and further dilute in 0.9% sodium chloride or 5% dextrose
  • Administer over 2 hours via IV infusion

Contraindications:

• Hypersensitivity to Ceftazidime, Avibactam, cephalosporins, or penicillins

Precautions:

• Perform a skin sensitivity test before administration in allergic patients
• Monitor renal function regularly, especially in critically ill patients
• Use with caution in patients with seizures or neurological disorders

Adverse Reactions:

• Gastrointestinal: Nausea, vomiting, diarrhea
• Allergic Reactions: Rash, pruritus, anaphylaxis (rare)
• Hematologic: Leukopenia, thrombocytopenia
• Hepatic: Elevated liver enzymes (ALT, AST)
• Neurological: Confusion, seizures (rare, mainly in renally impaired patients)

Drug Interactions:

• May enhance the nephrotoxicity of aminoglycosides
• May interact with probenecid, leading to reduced clearance of Avibactam

Storage Conditions:

• Store below 25°C, protect from light and moisture
• Reconstituted solution should be used within 12 hours at room temperature or 24 hours if refrigerated