Cefoperazone Sodium and Tazobactam Sodium for Injection 1g (10vials/box)

• Dosage Form: Powder Injection
• Transport Package: Carton
• Specification: 1g
• Trademark: Sinolead
• Origin: China
• Model NO.: Powder for Injection

Product Description

Basic Info.

 

Generic Name	Cefoperazone Sodium and Tazobactam Sodium For Injection
Strength	1g
Packing	10vials/box
Origin	China

Component:
Cefoperazone,Tazobactam.

Character:
This product is white or white crystalline powder, odorless; It is moisture-inducing.

Indications:

For the treatment of moderate and severe infections caused by β-lactamase-producing bacteria that are resistant to cefoperazone and sensitive to this product. Additional antibiotics are not necessary for the treatment of mixed infections caused by cefoperazone sensitive bacteria and β-lactamase resistant bacteria sensitive to cefoperazone. Lower respiratory tract infections: pneumonia, acute onset of chronic bronchitis, acute bronchitis, pulmonary abscess and other lung infections caused by sensitive bacteria such as Pseudomonas aeruginosa, Streptococcus pneumoniae and other Klebsiella genera, Haemophilus influenzae, Staphylococcus aureus, which produce β-lactamase. Urinary and reproductive system infections: acute pyelonephritis, acute onset of chronic pyelonephritis, complex urinary tract infections, endometritis, gonorrhea and other reproductive tract infections caused by β-lactamase-producing Escherichia coli, Proteus, Klebsiella, Pseudomonas aeruginosa, Staphylococcus and other sensitive bacteria. Abdominal and pelvic infections: peritonitis, cholecystitis, cholangitis and other abdominal infections and pelvic inflammation caused by Enterobacteria, Escherichia coli, Klebsiella, Pseudomonas aeruginosa, Citrobacter, Bacteroides peptostreptococcus and Clostridium. Other infections: septicaemia caused by the above beta-lactamase-producing gram-positive and gram-negative bacteria, meningitis caused by diplococcus meningitidis and Haemophilus influenzae, severe skin and soft tissue infections.

 

Usage and dosage:

Intravenous drip. Dissolve sodium chloride injection or sterilized water for injection in appropriate amount (5-10ml), and then add 5% glucose water or sodium chloride injection to dilute 150-250ml for intravenous infusion, infusion time is 30-60 minutes, and each infusion time is not less than 30 minutes. The course of treatment is generally 7 to 10 days (severe infection can be extended appropriately).

Adult dosage: 2g (1 vial) per dose, intravenously every 8 or 12 hours. Patients with severe renal insufficiency (myohepatic elimination rate < 30ml/min), the dose of tazobactam should not exceed 0.5g every 12 hours.

Precautions:

(1) Before using this product, the patient should be asked in detail whether there is a history of allergy to penicillins, cephalosporins and β-lactam inhibitors. Use with caution if allergic to penicillin antibiotics. During treatment, if allergic reaction occurs, the drug should be stopped immediately. Severe allergic reaction, should be immediately given adrenaline first aid, oxygen, intravenous corticosteroids.

(2) This product is sodium salt, and patients who need to control salt intake should check the serum electrolyte level regularly when using this product; Patients who are treated with cytotoxic drugs or diuretics should be alert to the possibility of hypokalemia.

(3) For patients with hepatic and renal dysfunction and severe biliary obstruction, the dosage and administration interval should be adjusted when using this product, and the blood concentration should be monitored.

(4) Some patients treated with this product can cause vitamin K deficiency and hypoprothrombinemia, and bleeding time and prothrombinemia time should be monitored during medication. At the same time, vitamin K1 can prevent the occurrence of bleeding.

(5) When using this product for a longer period of treatment, the patient's liver, kidney, blood and other system functions should be checked regularly.

(6) Patients should avoid drinking alcoholic beverages when applying this product. Parenteral administration of high nutritional preparations containing alcohol, such as nasal feeding, should also be avoided.

(7) When combined with aminoglycoside antibiotics, attention should be paid to monitoring renal function changes.

(8) Interference with diagnosis: false positive reaction can occur when urine sugar is determined by copper sulfate method, and positive reaction of direct antiglobulin (Coombs) test.