Parecoxib Sodium for Injection 40mg / High Quality

• Customization: Available
• Packaging From: 1+1/Box; 10 Vials /Box
• Packaging: Customization
• Model NO.: injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 40mg
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
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Parecoxib Sodium for Injection 40mg

Composition:

Each vial contains:

• Parecoxib Sodium 40mg

Description:

Parecoxib is a selective COX-2 inhibitor (NSAID) used for the short-term treatment of postoperative pain. It is a prodrug of Valdecoxib, providing rapid pain relief while minimizing gastrointestinal side effects associated with traditional NSAIDs.

Indications:

Parecoxib Sodium is indicated for:

• Short-term management of acute postoperative pain
• Pain relief in patients unable to take oral NSAIDs

Dosage & Administration:

Adults:

• Initial dose: 40mg IV or IM
• Maintenance dose: 20-40mg every 6-12 hours as needed
• Maximum dose: 80mg per day

Elderly Patients (≥65 years):

• Initial dose: 20mg IV or IM, then 10-20mg every 6-12 hours
• Maximum dose: 40mg per day

Patients with Hepatic Impairment:

• Moderate impairment: Reduce dose to 20mg initially, then 10mg every 12 hours
• Severe impairment: Use is not recommended

Patients with Renal Impairment:

• Severe renal impairment (CrCl <30 mL/min): Use with caution
• End-stage renal disease: Use is not recommended

Administration:

• IV Injection: Reconstitute with 1mL of sterile water for injection and administer slowly over 15 seconds
• IM Injection: Reconstitute with 1-2mL of sterile water for injection and inject into a large muscle
• Do not mix with other drugs or solutions containing opioids

Contraindications:

• Hypersensitivity to Parecoxib, Valdecoxib, or other NSAIDs
• Severe hepatic impairment
• Active gastrointestinal bleeding or peptic ulcer disease
• History of coronary artery bypass graft (CABG) surgery
• Severe renal impairment (CrCl <30 mL/min)

Precautions:

• Cardiovascular Risk: May increase the risk of heart attack and stroke with prolonged use
• Gastrointestinal Risk: May cause gastric ulcers and bleeding-use with caution in patients with a history of GI disorders
• Renal Effects: Can cause fluid retention, hypertension, and renal dysfunction-monitor renal function in at-risk patients
• Avoid in Pregnancy: Not recommended, especially in the third trimester

Adverse Reactions:

• Common: Nausea, vomiting, headache, dizziness, injection site pain
• Serious: Hypertension, renal dysfunction, gastrointestinal bleeding, allergic reactions (including anaphylaxis)

Drug Interactions:

• Anticoagulants (Warfarin, Heparin): Increased bleeding risk-monitor INR closely
• Diuretics & ACE Inhibitors: May reduce effectiveness-monitor blood pressure and kidney function
• Other NSAIDs or Corticosteroids: Increased risk of gastrointestinal bleeding
• Methotrexate & Lithium: May increase toxicity-monitor drug levels

Storage Conditions:

• Store below 25°C, in a dry place
• Protect from light and moisture
• Use reconstituted solution within 6 hours if stored at room temperature