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Meropenem for Injection 1.0g
Composition:
Each vial contains:
- Meropenem trihydrate (equivalent to 1.0 g Meropenem anhydrous)
- Sodium carbonate as a buffering agent
Description:
Meropenem is a broad-spectrum carbapenem antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs). It is resistant to most β-lactamases, making it effective against gram-positive, gram-negative, and anaerobic bacteria.
Indications:
Meropenem for Injection is indicated for the treatment of:
- Complicated intra-abdominal infections
- Complicated skin and soft tissue infections
- Community-acquired and hospital-acquired pneumonia
- Bacterial meningitis
- Complicated urinary tract infections (UTIs), including pyelonephritis
- Septicemia
Dosage & Administration:
Recommended Dosage (Adults & Adolescents ≥50 kg):
- Complicated Intra-Abdominal Infections: 1 g IV every 8 hours
- Complicated Skin & Soft Tissue Infections: 500 mg IV every 8 hours
- Community/Hospital-Acquired Pneumonia: 1 g IV every 8 hours
- Bacterial Meningitis: 2 g IV every 8 hours
- Complicated UTIs (Pyelonephritis): 500 mg-1 g IV every 8 hours
- Septicemia: 1 g IV every 8 hours
Pediatric Dosage (≥3 months to <50 kg):
- 10-20 mg/kg IV every 8 hours (Max: 2 g/dose)
Administration:
- Reconstitution:
- IV Injection (Bolus over 3-5 minutes): Reconstitute 1 g vial with 20 mL sterile water for injection
- IV Infusion (over 15-30 minutes): Reconstitute 1 g vial with 20 mL sterile water, then further dilute in 100 mL 0.9% NaCl or 5% Dextrose
- Do not mix with other drugs in the same IV line
Dose Adjustments:
- Renal Impairment (Creatinine Clearance <50 mL/min):
- 26-50 mL/min: 1 g every 12 hours
- 10-25 mL/min: 1 g every 24 hours
- <10 mL/min (including dialysis patients): 500 mg every 24 hours
- Hepatic Impairment: No adjustment needed
Contraindications:
- Hypersensitivity to Meropenem, other carbapenems, or β-lactam antibiotics
Precautions:
- Cross-sensitivity with penicillins and cephalosporins
- Seizure risk in patients with CNS disorders (e.g., epilepsy)
- Monitor liver and kidney function in prolonged use
Adverse Reactions:
- Common: Nausea, vomiting, diarrhea, headache, rash, injection site reactions
- Serious: Seizures, anaphylaxis, Clostridium difficile-associated diarrhea
Drug Interactions:
- Valproic Acid: May decrease valproic acid levels-consider alternative seizure treatment
- Probenecid: Increases Meropenem levels-avoid co-administration
Overdose & Management:
- Symptoms: Seizures, confusion, nausea, vomiting
- Treatment: Supportive care, hemodialysis for removal of drug
Storage Conditions:
- Store below 25°C, protect from light
- Use reconstituted solution within 3 hours at room temperature or 12 hours if refrigerated
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