| Customization: | Available |
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| Dossier: | Ctd,Actd |
| GMP: | Chinese GMP |
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| Generic Name | Cefalotin Sodium for Injection |
| Strength | 1g |
| Packing | 1vial/box |
| Origin | China |
This product is suitable for penicillin-resistant Staphylococcus aureus (except methicillin-resistant) and sensitive gram-negative bacteria caused by respiratory tract infection, soft tissue infection, urinary tract infection, septicemia, etc. In severe cases, it can be combined with aminoglycoside antibiotics, but it should be warned that it may increase renal toxicity. This product should not be used in patients with bacterial meningitis.
For adults, 0.5 ~ 1g (1 ~ 2 bottles) is given intramuscularly or intravenously, once every 6 hours. The daily dose for severely infected patients can be increased to 6 to 8g (12 to 16 bottles). To prevent infection after surgery, 1 ~ 2 (2 ~ 4 bottles) g can be given 0.5 ~ 1 hour before surgery, and 1 ~ 2g (2 ~ 4 bottles) can be given during surgery if the operation time is more than 3 hours. According to the condition, the drug can be given once every 6 hours after surgery, and the drug can be stopped within 24 hours after surgery. For heart surgery, artificial arthroplasty, etc., prophylactic application can be maintained for 2 days after surgery. The maximum daily dose for adults should not exceed 12g (24 vials). Children were given four doses according to body weight 50 ~ 100mg/kg daily. Newborns within 1 week are 20mg/kg per body weight every 12 hours; 20mg/kg every 8 hours for more than 1 week.
The use of this product in patients with renal dysfunction should be reduced appropriately. Creatinine clearance of less than 10ml/ min, 25ml/ min, 50ml/ min, and 80ml/ min was given at doses of 0.5g (1 bottle), 1g (2 bottles), 1.5g (3 bottles), and 2g (4 bottles) every 6 hours, respectively. The maintenance dose for anuria patients is 1.5g (3 vials) per day, divided into 3 doses. Hemodialysis and peritoneal dialysis can effectively clear this product, and 1g (2 bottles) should be given every 6 to 12 hours during dialysis to maintain the effective blood concentration.
Formulation of muscle injection: 1g (2 bottles) of this product and 4ml of sterilized water for injection to dissolve. For intravenous injection, 1g (2 bottles) of this product can be dissolved in 10ml sterilized water for injection, 5% glucose injection or sodium chloride injection, and the prepared solution can be slowly injected within 3 to 5 minutes. For intravenous infusion, dissolve 4g (8 bottles) of this product in 20ml sterilized water for injection, and then dilute it appropriately. When administered intraperitoneally, 60mg of cefalothiophene sodium is generally contained per 1000ml of dialysate. The concentration of cephalothiophene sodium applied after the treatment of peritonitis or abdominal contamination can reach 0.1% to 4%.
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