| Dossier: | Ctd |
|---|---|
| Transport Package: | Carton |
| Specification: | 300mg |
| Trademark: | Sinolead |
| Origin: | China |
| Samples: |
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| Customization: |
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| Generic Name | Rifampicin Capsules 300mg |
| Strength | 300mg |
| Packing | 10capsules/blister,10blisters/box |
| Origin | China |
1. This product is used in combination with other antituberculous drugs for the primary and secondary treatment of various types of tuberculosis, including the treatment of tuberculous meningitis.
2. This product is used in combination with other drugs for the treatment of leprosy and non-tuberculous mycobacterium infection.
3. This product can be used in combination with Vancomycin (IV) for severe infections caused by methicillin-resistant staphylococcus. The combination of rifampicin and erythromycin is used for severe Legionella infections.
4. For asymptomatic carriers of Neisseria meningitidis to eliminate Neisseria meningitidis in nasopharynx; It does not apply to the treatment of Neisseria meningitidis.
1. Anti-tuberculosis treatment: adults, oral, 0.45g ~ 0.60g a day, taken on an empty stomach, no more than 1.2g a day; Children over 1 month old should be taken daily on an empty stomach according to their body weight of 10 ~ 20mg/kg, and the daily amount should not exceed 0.6g (4 capsules).
2. Neisseria meningititicus carrier: adults 5mg/kg, once every 12 hours, for 2 consecutive days; Children over 1 month old 10mg/kg daily, once every 12 hours, four times in a row.
3. Elderly patients: Oral, according to 10mg/kg per day, empty stomach.
Precautions:
1. Use with caution in patients with alcoholism and liver function damage. Use with caution for infants, pregnant women over 3 months and lactating women.
2. Interference with diagnosis: it can cause positive direct antiglobulin test (Coombs test); Interference with the determination of serum folate concentration and serum vitamin B12 concentration; It can make the sulfonobromphthalide sodium test stay false positive; May interfere with the results of urine analysis tests performed by means of spectrophotometers or colour changes; It can increase the concentration of blood urea nitrogen, serum alkaline phosphatase, serum alanine aminotransferase, aspartate aminotransferase, serum bilirubin and serum uric acid.
3. Rifampicin can cause liver insufficiency, and icterus death cases have been reported in patients with pre-existing liver disease or when taken with other hepatotoxic drugs. Therefore, patients with pre-existing liver disease should be used with caution only when there are clear indications.
4. Hyperbilirubinemia is a combination of hepatocellular and biliary retention. Patients with mild cases will resolve spontaneously during medication, while patients with severe cases will need to stop medication for observation. Elevated blood bilirubin may also be the result of rifampicin competing with bilirubin for excretion. The changes of liver function should be closely monitored during the first 2 to 3 months of treatment.
5. Rifampicin alone can rapidly develop resistance to tuberculosis or other bacterial infections, so it must be used in combination with other drugs. Treatment may last six months to two years, or even years.
6. Rifampin may cause leukopenia and thrombocytopenia, and lead to gingival bleeding and infection, delayed wound healing, etc. At this time, tooth extraction and other operations should be avoided, and pay attention to oral hygiene, brushing and picking teeth should be careful until blood images return to normal. Peripheral blood images should be checked regularly during medication.
7. Rifampicin should be taken l hours before or 2 hours after a meal. It is best to take rifampicin once on an empty stomach in the morning because eating affects the absorption of Rifampicin.
8. Patients with hypohepatic function often need to reduce the dose, daily dose ≤8mg/kg.
9. There is no need to reduce the amount of renal function. There was no significant change in rifampicin serum concentration in patients with reduced glomerular filtration rate or no urine.
10. After taking the medicine, urine, saliva, sweat and other excrement can be orange red. There is a possibility of interstitial nephritis.
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