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Generic Name | Tenofovir Alafenamide Fumarate tablets 25mg |
Strength | 25mg |
Packing | 30tabs/box |
Origin | China |
Tablets.
It is indicated for the treatment of adults with chronic hepatitis B virus (HBV) infection and children with compensatory liver disease aged 12 years and older (weighing at least 35kg)
Matters needing attention:
1. Severe acute exacerbation of hepatitis B after drug withdrawal
Discontinuation of anti-hepatitis B therapy, including tenofovir and phenolamine, may result in severe acute exacerbation of hepatitis B. Discontinuation patients should be closely monitored for at least several months after discontinuation of treatment, with clinical and laboratory follow-up. If appropriate, it may be necessary to resume anti-hepatitis B therapy.
2. Risk of HIV-1 resistance in patients co-infected with HBV and HIV-1
Due to the risk of developing HIV-1 resistance, Tenofovir alphenolamine alone is not recommended for the treatment of HIV-1 infection, and its safety and efficacy in patients co-infected with HBV and HIV-1 have not been proven. Before starting treatment, all HBV-infected patients should be tested for HIV antibodies, and if positive, the appropriate combination antiretroviral regimen recommended for patients co-infected with HIV-1 should be used.
3. New or aggravated kidney damage
Patients with impaired renal function taking pretenofovir and patients taking nephrotoxic drugs, including NSaids, are at increased risk for nephro-related adverse events
Serum creatinine was assessed and creatinine clearance, urinary glucose, and urinary protein were estimated in all patients before or while taking the drug, and during clinically appropriate tenofovir and alphenamine therapy. Serum phosphorus is also evaluated in patients with chronic kidney disease.
4. Lactic acidosis/severe hepatomegaly with steatosis
Treatment should be discontinued in any patient whose clinical or laboratory findings suggest lactic acidosis or significant hepatotoxicity, which may include hepatomegalysis and steatosis, even without significant aminotransferase elevation