| Transport Package: | Free |
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| Specification: | 1.5g |
| Trademark: | Sinolead |
| Origin: | China |
| Samples: |
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| Customization: |
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| Generic Name | Ampicillin Sodium and Sulbactam Sodium for Injection 1.5g |
| Strength | 1.5g |
| Packing | 10 vials/box,1vial+10ml WFI/box |
| Origin | China |
This product is white or white powder.
This product is suitable for the treatment of infections caused by sensitive bacteria. Typical indications include sinusitis, otitis media, epiglottitis, bacterial pneumonia and other upper and lower respiratory tract infections; Urinary tract infection, pyelonephritis; Peritonitis, cholecystitis, endometritis, pelvic cellulitis and other intraperitoneal infections; Bacterial bacteremia; Skin, soft tissue, bone, joint infection; Gonococcal infection.
In the perioperative period, it can also be injected to reduce the incidence of wound infection in patients after abdominal and pelvic surgery. Wound infection can be secondary to peritoneal infection. During pregnancy termination or caesarean section, sulbactam sodium for injection and ampicillin sodium can be used prophylactically to reduce the risk of post-operative sepsis.
Usage and dosage:
For intravenous administration, sulbactam sodium for injection and ampicillin sodium should be prepared using sterile water for injection or other compatible solutions. To ensure complete dissolution, wait until the powder is no longer visible to the naked eye after the foam has disappeared. This dose can be used for intravenous infusion, which should last for more than 3 minutes, or to increase the volume of the diluent, which should be administered by intravenous infusion, which should last for more than 15-30 minutes.
Subactam sodium for injection and ampicillin sodium for parenteral administration can be used for deep intramuscular injection. If pain occurs at the injection site, the powder can be prepared with 0.5% anhydrous lidocaine hydrochloride sterilized water for injection.
Adult usage
The usual daily dose of sulbactam sodium for injection and ampicillin sodium is 1.5-12 grams, graded doses are injected every 6 or 8 hours, and the maximum daily dose of sulbactam is 4 grams. To treat mild and moderate infections, injections can be given every 12 hours.
Severity of infection Daily dose of sulbactam sodium for injection ampicillin sodium (g)
Mild 1.5-3 (0.5+1 to 1+2)
Moderate maximum dose 6 (2+4)
Severe maximum dose 12 (4+8)
The number of dosages may be increased or decreased depending on the severity of the patient's infection and renal function. Treatment usually lasts until 48 hours after the patient's fever has subsided or other abnormal signs have returned to normal. In general, it should be treated for 5-14 days, but in severe cases, the course of treatment can be extended or ampicillin can be added.
When treating infections in patients with limited sodium intake, it should be noted that 1500 mg of Subactam sodium for injection and ampicillin sodium contains approximately 115 mg (5 mmol) of sodium salt.
When used to prevent surgical infection, 1.5-3 grams of Subactam sodium for injection and ampicillin sodium should be given to patients during induction of anesthesia to allow sufficient time for the drug to reach effective serum and tissue concentrations during surgery. This dose can be repeated every 6-8 hours; The drug is usually discontinued 24 hours after the major surgical procedure, except when subactam sodium for injection and ampicillin sodium are used for treatment.
For the treatment of uncomplicated gonorrhea, a single dose of 1.5 grams of sulbactam sodium for injection and ampicillin sodium can be injected. To prolong the plasma concentrations of sulbactam and ampicillin, 1.0 g of prosulfa should be taken orally.
Medication for patients with impaired renal function
Patients with severe renal impairment (creatinine clearance < 30 ml/min), the pharmacokinetic parameters of sulbactam and ampicillin were similarly affected, so the ratio of plasma concentrations between the two remained constant. As usual with ampicillin, sulbactam/ampicillin should be administered less frequently in these patients.
Matters needing attention:
Severe or occasionally fatal allergic reactions have been reported in patients treated with penicillin-based antibiotics, including sulbactam sodium for injection and ampicillin sodium. These allergic reactions are more likely to occur in patients with a history of penicillin allergy and/or allergic reactions to multiple allergens. Patients with a history of penicillin allergy have also reported severe allergic reactions when treated with cephalosporins. Prior to penicillin treatment, patients should be carefully asked about their history of allergic reactions to penicillins, cephalosporins, and other allergens. In the event of anaphylaxis, the drug should be discontinued and properly treated.
In case of severe allergic reactions, immediate emergency treatment with epinephrine, oxygen inhalation, intravenous hormone injection, and ventilation including tracheal intubation should be taken according to the condition.
As with any antibiotic, patients should be continuously monitored for signs of insensitive microorganisms, including fungal overgrowth. Once a double infection occurs, the drug should be discontinued and properly managed.
As with any other effective drug for systemic use, it is recommended that patients be regularly checked for organ and system dysfunction, including kidney, liver and hematopoietic system, during extended treatment. This is especially important for newborns, especially premature infants and other infants.
Because infectious mononucleosis is caused by a viral infection, sulbactam sodium for injection and ampicillin sodium should not be used to treat it. Ampicillin treatment in patients with infectious mononucleosis may increase the incidence of rashes.
Intradermal sensitivity test of penicillin sodium should be done before use, and positive reaction should be prohibited.
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