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| Certified: | GMP |
| Dossier: | Ctd |
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Rifampicin Capsules 0.15g
Each capsule contains Rifampicin 0.15g (150mg).
Rifampicin Capsules 0.15g are a rifamycin-class antibiotic primarily used to treat tuberculosis (TB) and other bacterial infections. Rifampicin works by inhibiting bacterial RNA synthesis, making it effective against a wide range of gram-positive and gram-negative bacteria, including Mycobacterium tuberculosis.
Rifampicin is indicated for:
Treatment of tuberculosis (TB): As part of a combination therapy regimen.
Prophylaxis of meningococcal meningitis: In close contacts of infected individuals.
Treatment of other infections: Such as leprosy, brucellosis, and staphylococcal infections.
Adults:
Tuberculosis: 10mg/kg body weight (usually 450-600mg) once daily, as part of a combination therapy.
Meningococcal prophylaxis: 600mg twice daily for 2 days.
Children:
Tuberculosis: 10-20mg/kg body weight once daily, not exceeding 600mg per day.
Meningococcal prophylaxis: 10mg/kg twice daily for 2 days.
Administration: Swallow the capsule whole with water. Take on an empty stomach (1 hour before or 2 hours after meals) for optimal absorption.
Common side effects may include:
Gastrointestinal disturbances (e.g., nausea, vomiting, diarrhea)
Orange-red discoloration of body fluids (e.g., urine, sweat, tears)
Headache or dizziness
Serious side effects (e.g., hepatotoxicity, flu-like symptoms, severe allergic reactions) are rare but require immediate medical attention.
Hypersensitivity to rifampicin or any component of the formulation.
Severe liver disease or jaundice.
Concurrent use with certain medications (e.g., saquinavir/ritonavir).
Consult a doctor before use if you have a history of liver disease, alcohol dependence, or porphyria.
Regular monitoring of liver function tests is recommended during treatment.
Rifampicin may reduce the effectiveness of hormonal contraceptives. Use alternative contraceptive methods.
Anticoagulants (e.g., warfarin): Rifampicin may reduce their effectiveness. Monitor INR closely.
Antiretroviral drugs (e.g., protease inhibitors, NNRTIs): Rifampicin may decrease their plasma concentrations.
Corticosteroids, oral hypoglycemics, and anticonvulsants: Rifampicin may reduce their efficacy.
Store in a cool, dry place (below 25°C), away from direct sunlight. Keep out of reach of children.
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