Metamizole Sodium Injection 2ml: 500mg / High Quality

• Customization: Available
• Packaging From: 10 Ampoules/Box
• Packaging: Customization
• Model NO.: Injection
• Dosage: Ready
• Transport Package: Shipping
• Specification: 2ml: 500ml
• Trademark: brand
• Origin: China

Product Description

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Metamizole Sodium Injection 2ml: 500mg

Composition:

Each 2ml ampoule contains:

• Metamizole Sodium .........… 500mg
• Excipients: Water for Injection

Description:

Metamizole Sodium, also known as Dipyrone, is a non-opioid analgesic and antipyretic with spasmolytic properties. It is commonly used for pain relief, fever reduction, and smooth muscle spasms.

Indications:

Metamizole Sodium Injection is indicated for the treatment of:

• Moderate to severe pain, including post-operative pain, trauma, and colic
• High fever unresponsive to other antipyretics
• Pain associated with spasms of the gastrointestinal, biliary, or urinary tract

Dosage & Administration:

Adults and Adolescents (≥15 years, ≥53 kg):

• Single dose: 500mg - 1000mg (1-2 ampoules)
• Maximum daily dose: 5000mg (10 ampoules)
• Administration: Slow intravenous (IV) injection over 5 minutes or deep intramuscular (IM) injection

Children and Adolescents:

• Dosage based on body weight: 6-16 mg/kg per dose
• Administered as IV infusion or IM injection under medical supervision

Administration Guidelines:

• IV injection: Must be given slowly (over ≥5 minutes) to prevent hypotension
• IM injection: Deep intramuscular administration is recommended
• Dilution: If required, dilute with 0.9% Sodium Chloride or 5% Dextrose Injection

Contraindications:

• Hypersensitivity to Metamizole or other pyrazolone derivatives
• Bone marrow suppression or pre-existing blood disorders (e.g., agranulocytosis)
• Severe hepatic or renal impairment
• Pregnancy (especially third trimester) and lactation
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency

Warnings & Precautions:

• Risk of agranulocytosis (monitor for signs of infection)
• Hypotension risk (especially with IV use)
• Caution in patients with asthma or NSAID hypersensitivity
• Avoid prolonged use to reduce the risk of blood dyscrasias

Adverse Reactions:

• Common: Hypotension, dizziness, nausea
• Serious: Agranulocytosis, anaphylactic shock, leukopenia, severe skin reactions (e.g., Stevens-Johnson syndrome)

Drug Interactions:

• Cyclosporine: May reduce cyclosporine levels
• NSAIDs & anticoagulants: Increased risk of bleeding
• CYP2B6 and CYP3A4 inhibitors/inducers: May affect metabolism

Overdose & Management:

• Symptoms: Nausea, vomiting, abdominal pain, renal impairment, convulsions
• Treatment: Supportive care, IV fluids, activated charcoal if ingested

Storage Conditions:

• Store below 25°C
• Protect from light
• Use immediately after opening