| Generic Name |
Miconazole Nitrate Vaginal Suppository |
| Strength |
400mg |
| Packing |
3 suppositories/box |
| Origin |
China |
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Product name:
Miconazole Nitrate Vaginal Suppository 400mg
Character:
This product is white oval suppository.
Indications:
Vaginal infection caused by candida and repeated infection caused by gram-positive bacteria.
Adverse reactions:
A few cases have local irritation, itching and burning sensation, most of which occur in the early stage of treatment.
Pharmacology and toxicology:
Pharmacology and toxicology: Miconazole has anti-dermal fungi, yeast activity, and some gram-positive spheres and bacilli. Miconazole inhibits fungal ergosterol biosynthesis, which changes the lipid composition of cell membrane and leads to bacterial death.
Matters needing attention:
1.If allergic reactions to local irritation occur, the drug should be discontinued.
2. Pay attention to hygiene, control infection and reinfection factors, if the spouse has infection should also be properly treated.
3. Despite limited vaginal absorption, pregnant women who have had within the first three months of pregnancy should still weigh the pros and cons of use. There is no data on whether this lui is secreted by breast milk, but nursing women should pay attention to it.
This product is a pyrrole antifungal drug, a dechlorinated derivative of miconazole. It has antibacterial activity against Candida, pigmentomyces, Coccidioides, histoplasmosis, Sporotrichophyton, etc. It also has antibacterial activity against trichophyton trichophyton. This product has poor effect on Aspergillus, Sporotrichothrix Schenckii, some fusarium families, Mucor genera, etc.
The mechanism of action is to interfere with the activity of cytochrome P450, thus inhibiting the biosynthesis of ergosterol, the main sterol in fungal cell membrane, damaging the fungal cell membrane and changing its permeability, resulting in the leakage of important intracellular substances. This product can inhibit the biosynthesis of triacylglycerol and phospholipids of fungi, inhibit the activity of oxidase and peroxidase, and cause intracellular hydrogen peroxide accumulation leading to cell submicrostructure degeneration and cell necrosis. Candida albicans can inhibit the process of its transformation from spore to aggressive mycelium.
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