GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg

Product Details
Customization: Available
Quality Standard: USP, Bp
Usage Mode: Injection
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  • GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg
  • GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg
  • GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg
  • GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg
  • GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg
  • GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg
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Basic Info.

Model NO.
injection
Factory Certified
GMP
Transport Package
Carton
Specification
40mg
Trademark
Sinolead
Origin
China
Production Capacity
100000ctns Per Month

Product Description

Generic Name Methylprednisolone Sodium Succinate for injection 40mg
Strength 40mg
Packing 10 vials /box
Origin China
 
 
Value-added services:
 Packaging design by our team
 
Registration service by our team

 Registration dossier available by our team
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Product name:
Methylprednisolone Sodium Succinate for injection 40mg

Character:
 The 40mg size of this product is a two-chamber bottle, the lower chamber is white to quasi-white freeze-dried lump or powder, and the upper chamber is colorless and clear liquid.


Indications:
Indications are that unless used as an alternative treatment for some endocrine diseases, glucocorticoids are only a symptomatic treatment.

Adverse reactions:
Systemic side effects may be observed. Although it rarely occurs during short-term treatment, careful follow-up is still necessary. This is part of the follow-up of steroid therapy and is not specific to a particular drug. Possible adverse effects of glucocorticoids (such as methylprednisolone) are:
Infections and invasions: infections, opportunistic infections.
Immune system abnormalities: Drug allergy (including similar or severe anaphylaxis with or without circulatory collapse, cardiac arrest, bronchospasm).
Endocrine abnormalities: Cushing syndrome, hypopituitarism, steroid withdrawal syndrome.
Metabolic and nutritional abnormalities: impaired glucose tolerance, hypokalemic alkalosis, dyslipidemia, increased need for insulin or oral hypoglycemic agents in diabetic patients. Sodium retention, fluid retention, negative nitrogen balance (caused by protein breakdown), increased blood urea nitrogen, increased appetite (which may lead to weight gain), and hyperliposis.
Psychotic disorders: Affective disorders (including mood instability, low mood, euphoria, psychological dependence, suicidal ideation), psychotic disorders (including mania, delusions, hallucinations, schizophrenia [aggravated]), hazy states of consciousness, mental disorders, anxiety, personality changes, mood swings, behavioral abnormalities, insomnia, irritability.
Neurological abnormalities: increased intracranial pressure (possible papilledema [benign cranial hypertension], convulsions, forgetfulness, cognitive impairment, dizziness, headache.
Eye abnormalities: eye abnormalities, glaucoma, cataracts.
Abnormal ear and labyrinth: vertigo.
Cardiac abnormalities: congestive heart failure (susceptible patients), arrhythmia.
Vascular abnormalities: hypertension, hypotension.
Respiratory system, chest and mediastinum abnormalities: hiccups.
Gastrointestinal abnormalities: stomach bleeding, intestinal perforation, digestive ulcer (peptic ulcer perforation and peptic ulcer bleeding may occur), pancreatitis, peritonitis, ulcerative esophagitis, esophagitis, abdominal pain, bloating, diarrhea, indigestion, nausea.
Skin and subcutaneous tissue abnormalities: angioedema, peripheral edema, ecchymosis, petechiae, skin atrophy, striated skin, hypopigmentation, hirsutism, rash, erythema, pruritus, urticaria, acne, hyperhidrosis.
Musculoskeletal and connective tissue abnormalities: osteonecrosis, pathological fractures, developmental delays (in children), muscular dystrophy, myopathy, osteoporosis, neuropathic joint disease, joint pain myalgia, myasthenia.
Reproductive system and breast abnormalities: menstrual disorders.
Systemic abnormalities and administration site conditions: poor healing, injection site reactions, fatigue, discomfort.
Examination: elevated alanine aminotransferase, elevated aspartate aminotransferase, elevated blood alkaline phosphatase, elevated intraocular pressure, decreased glucose tolerance, decreased blood potassium, increased urinary calcium, inhibited skin test reaction.
Injuries, poisonings and operational complications: tendon rupture (especially Achilles tendon), vertebral compression fracture.

Pharmacology and toxicology:

This product is methylprednisolone for intravenous and intramuscular injection. It is a synthetic glucocorticoid. This highly concentrated aqueous solution is particularly suitable for disease states requiring strong, fast-acting hormone therapy. Methylprednisolone has strong anti-inflammatory, immunosuppressive and anti-allergic activities.
Glucocorticoids diffuse through cell membranes and bind to specific receptors in the cytoplasm. This binding then enters the nucleus, binds to DNA(chromosomes), initiates transcription of mRNA, and then synthesizes various enzyme proteins, which are believed to be the ultimate source of glucocorticoids for their various systemic effects. Glucocorticoids not only play an important role in inflammation and immune processes, but also affect carbohydrate, protein and fat metabolism, and also have an effect on the cardiovascular system, the skeletal musculoskeletal system and the central nervous system.
-- Acts on inflammatory and immune processes:
Most of the therapeutic effects of glucocorticoids are related to its anti-inflammatory, immunosuppressive, and anti-allergic properties, which lead to the following outcomes:
- Reduce inflammation around the lesions of immune active cells
- Reduces blood vessel dilation
- Stable lysosomal membrane
- Inhibition of phagocytosis
- Reduces the production of prostaglandins and related substances
Methylprednisolone has only a very low salt corticosteroid effect (200mg of methylprednisolone is equivalent to 1mg of deoxycorticosterone).
- Effects on carbohydrate and protein metabolism:
Glucocorticoids have the function of breaking down protein, and the released amino acids are converted into glucose and glycogen in the liver through gluconeogenesis. At the same time, the absorption of glucose by peripheral tissues is reduced, resulting in elevated blood sugar and glycosuria. This is especially true for those who are predisposed to diabetes.
-- Effects on fat metabolism:
Glucocorticoids have the function of breaking down fat, which mainly affects the limbs; In addition, glucocorticoids also have a fat synthesis effect, which is particularly obvious in the chest, neck and head. All this leads to a redistribution of fat.
The maximum pharmacological effect of glucocorticoids occurred after peak blood concentrations, suggesting that most of their effects were induced by altering enzyme activity rather than by direct action of the drug.


Storage:
Undissolved medicine, sealed, 15-25ºC store
The solution dissolved with the included diluent can be stored at room temperature (15-25 ° C) for 48 hours.

GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mgGMP Certified / Methylprednisolone Sodium Succinate for Injection 40mgGMP Certified / Methylprednisolone Sodium Succinate for Injection 40mgGMP Certified / Methylprednisolone Sodium Succinate for Injection 40mgGMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg
GMP Certified / Methylprednisolone Sodium Succinate for Injection 40mgGMP Certified / Methylprednisolone Sodium Succinate for Injection 40mgGMP Certified / Methylprednisolone Sodium Succinate for Injection 40mgGMP Certified / Methylprednisolone Sodium Succinate for Injection 40mg

 

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