Cefoperazone Sodium and Tazobactam Sodium for Injection 1g / High Quality

• Customization: Available
• Packaging From: 10 Vials /Box
• Packaging: Customization
• Model NO.: Powder for injection
• Dosage: Ready
• Certified: GMP
• Transport Package: Shipping
• Specification: 1g
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
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Cefoperazone Sodium and Tazobactam Sodium for Injection 1g

Composition:

Each vial contains:

• Cefoperazone Sodium - 1g
• Tazobactam Sodium - (proportionate to Cefoperazone, usually 1:1 or 2:1 ratio)

Description:

Cefoperazone is a third-generation cephalosporin with broad-spectrum antibacterial activity, including Pseudomonas aeruginosa. Tazobactam is a β-lactamase inhibitor that enhances cefoperazone's activity against β-lactamase-producing bacteria.

Indications:

Cefoperazone Sodium and Tazobactam Sodium for Injection is used for the treatment of infections caused by susceptible organisms, including:

• Respiratory tract infections (pneumonia, bronchitis)
• Urinary tract infections (complicated and uncomplicated)
• Intra-abdominal infections (peritonitis, cholecystitis)
• Septicemia (bacteremia caused by susceptible organisms)
• Skin & soft tissue infections (cellulitis, abscesses)
• Gynecological infections (pelvic inflammatory disease, endometritis)
• Bone and joint infections
• Meningitis (caused by susceptible bacteria)

Dosage & Administration:

Intravenous (IV) or Intramuscular (IM) Use

Adults & Children (>12 years, >40 kg):

• Mild to moderate infections: 1-2g every 12 hours
• Severe infections: 2-4g every 8-12 hours
• Nosocomial pneumonia, septicemia: 3-4g every 8 hours

Children (2 months to 12 years, <40 kg):

• 50-100 mg/kg/day divided into 2 doses
• Severe infections: Up to 200 mg/kg/day

Reconstitution & Administration:

• IV injection: Dissolve 1g vial in 10mL sterile water, administer slowly over 3-5 minutes
• IV infusion: Further dilute in 50-100mL normal saline or 5% dextrose, infuse over 30 minutes
• IM injection: Dissolve 1g vial in 2-3mL sterile water or lidocaine 0.5% (for pain reduction)

Contraindications:

• Hypersensitivity to cephalosporins, β-lactam antibiotics, or penicillins
• History of severe allergic reactions (e.g., anaphylaxis, angioedema)

Precautions:

• Use with caution in renal or hepatic impairment (dose adjustment may be required)
• Monitor for Clostridium difficile-associated diarrhea (CDAD)
• May affect blood clotting (monitor PT/INR in prolonged use or liver disease patients)

Adverse Reactions:

• Common: Nausea, vomiting, diarrhea, rash, pain at injection site
• Serious: Anaphylaxis, Clostridium difficile colitis, bleeding tendency, liver enzyme elevation

Drug Interactions:

• Aminoglycosides & diuretics (e.g., furosemide): Increased risk of nephrotoxicity
• Anticoagulants (e.g., warfarin): Increased risk of bleeding
• Alcohol (disulfiram-like reaction): Avoid alcohol consumption

Overdose & Management:

• Symptoms: Neurotoxicity (seizures, confusion), renal dysfunction
• Treatment: Supportive care, hemodialysis if necessary

Storage Conditions:

• Store below 25°C, protect from light and moisture
• Use reconstituted solution within 12 hours (if stored at room temperature) or 24 hours (if refrigerated)