| Dosage Form: | Powder Injection |
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| Transport Package: | Carton |
| Specification: | 1g |
| Trademark: | Sinolead |
| Origin: | China |
| Samples: |
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| Customization: |
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| Generic Name | Cefoperazone Sodium and Sulbactam Sodium for Injection 1g |
| Strength | 1g |
| Packing | 1vial+1Ampoule/box |
| Origin | China |
This product is used to treat the following infections caused by sensitive bacteria:
Respiratory infections (upper and lower respiratory tract); Urinary tract infection (upper and lower urinary tract); Peritonitis, cholecystitis, cholangitis and other abdominal infections; Septicemia, meningitis; Skin and soft tissue infections, eye infections, bone and joint infections; Pelvic inflammatory disease, endometritis, gonorrhea and other genital, tract infections, etc. Prevent postoperative infection due to abdominal, gynecological, cardiovascular, orthopaedic and plastic surgery.
Usage and dosage:
Intramuscular or intravenous.
The daily dosage for adults was calculated as 1 ~ 2g according to the amount of cefoperazone, divided into equal amounts, and injected once every 12 hours. For severe or refractory infections, the daily dose may be increased to 8g, divided into equal doses, administered every 12 hours. But the total amount of sulbactam should not exceed 4g per day.
In patients with severe renal insufficiency, the administration schedule should be adjusted appropriately due to the decreased clearance rate of sulbactam. For patients with creatinine clearance between 16 and 30ml/ min, the maximum dosage of sulbactam should not exceed 1g every 12 hours. Such as creatinine clearance. 15ml/ min, the dosage of this product should not exceed 0.5g sulbactam every 12 hours.
Intramuscular injection:
This product is directly dissolved with 4ml sterilized injection water per 1.5g (3ml for 0.75g specification) and injected deep into the muscle. If it is necessary to add gallidocaine, it should be added after dissolving the product with water for sterilization injection. Do not dissolve the product directly with lidocaine injection, otherwise it will cause turbidity or precipitation.
Intravenous injection:
Dissolve the product first in 5ml for 0.75g and 1.5g or 10ml sterilized water for 2.25g and 3.0g or 0.9% sodium chloride injection for 2.25g and 3.0g, and then add the solution to appropriate infusion for intravenous or drip injection. Common infusions that can be used to dilute this product are: 0.9% sodium chloride injection, 5% glucose injection, glucose sodium chloride injection, 10% glucose injection.
If diluted with Ringer's solution, the product must be dissolved with sterilized water for injection before slowly adding to Ringer's solution, otherwise milky precipitate will occur.
1. Prior to the application of cefoperazone-sulbactam, the patient must be asked in detail whether there is a history of prior allergy to this product, other cephalosporins, penicillins or other drugs, as there may be cross-allergic reactions between penicillins and cephalosporins and other beta-lactam antibiotics. About 5%~10% of patients allergic to penicillin antibiotics may have cross-allergic reactions to cephalosporins. Therefore, patients with a history of penicillin allergy should use this product carefully under close observation after fully weighing the advantages and disadvantages. When using this product, in case of allergic reaction, you should stop immediately. In case of anaphylactic shock, immediate rescue should be carried out, including emergency measures such as epinephrine, maintaining airway patency, oxygen inhalation, glucocorticoids and antihistamines.
Medication for special population:
The concentration of this product is very low in the milk of lactating women, but it should still be used with caution during pregnancy and lactation.
Drug interaction:
This product has synergistic effect with aminoglycoside antibiotics, but there is incompatibility between the two. If necessary, it should be dissolved and diluted separately before infusion.
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