GMP Certified / Nicardipine Hydrochloride Injection 10mg

• Quality Standard: Bp, USP
• Ctd Dossier: Ready
• Documentation: Copp, COA
• Factory Certification: GMP
• Transport Package: Carton
• Specification: 10mg
• Model NO.: injection
• Trademark: Sinolead
• Origin: China
• Production Capacity: 100, 000, 000 Per Year

Product Description

Product Description

Generic Name	Nicardipine Hydrochloride Injection
Strength	10mg
Packing	10 amps/box
Origin	China

Value-added services:
 Packaging design by our team
 Registration service by our team
 Registration dossier available by our team
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Product name:
Nicardipine Hydrochloride Injection 10mg

Character:
 This product is light yellow clear liquid.

Indications:
1. Emergency treatment of abnormal hypertension during operation;
2. Hypertension emergency.

Adverse reactions:
1) Paralytic ileus (incidence unknown) : Paralytic ileus may occur, and when these abnormalities are found, administration should be stopped and appropriate treatment should be performed.
2) Hypoxemia (less than 0.1 to 5%) : Hypoxemia may occur, and the drug should be stopped and properly disposed of when these abnormalities are found.
3) Pulmonary edema, dyspnea (each less than 0.1%) : there may be pulmonary edema, dyspnea, when these symptoms are found to stop the drug, for appropriate treatment.
4) Angina pectoris (unknown incidence) : There are reports abroad that less than 1% of patients with coronary artery disease have angina pectoris or aggravation after treatment with this injection. When these symptoms occur, the medication should be stopped and appropriate treatment should be carried out.
5) Thrombocytopenia (less than 0.1%) : Thrombocytopenia may occur, so it should be carefully observed, when these abnormalities are found, stop the drug, and give appropriate disposal.
6) Abnormal liver function (less than 0.1 ~ 5%), jaundice (incidence unknown) : there may be AST(GOT), ALT(GPT), γ-GTP elevated liver function abnormalities and jaundice, so should be fully observed, when these abnormalities are found, stop the administration, and give appropriate treatment.

Pharmacological action:
This product is mainly metabolized by CYP3A4, and should be used with caution when combined with the following drugs:
1 When combined with antihypertensive drugs and beta-blockers, there is a pharmacologic addition of blood pressure reduction. A drug should be reduced or discontinued if necessary.
2 Reduced blood pressure when combined with fentanyl. A drug should be reduced or discontinued if necessary.
3 Cimetidine, HIV protease inhibitors, pyrrole antifungal drugs can inhibit the liver drug metabolism enzyme P450, increase the concentration of drugs in the blood, and increase the effect of this product.
4 Sometimes enhances the effect of digoxin, mainly because the clearance capacity of the kidney is reduced, so that the concentration of digoxin in the blood is increased. Reduce the amount of digoxin if necessary.
5 Because the protein binding rate of this product is relatively high, the competitive binding of plasma proteins increases the free type of phenytoin, and phenytoin can induce drug metabolizing enzymes in the liver and promote drug metabolism of calcium antagonists. If necessary, reduce the dosage of phenytoin or increase the dosage of this product.
6 Rifampicin induces drug metabolizing enzymes in the liver, promotes the metabolism of calcium antagonists, sometimes weakens the effect of this drug, and increases the dosage of this product when necessary.
7 Immunosuppressants such as cyclosporine can competitively inhibit the drug metabolism enzyme P450 in the liver, increase the concentration of immunosuppressants or this product in the blood, and reduce the dosage of immunosuppressants and this product when necessary.
8 This product can cause a decrease in muscle contractile force and may enhance the effect of muscle relaxants such as pancuronin. The dosage of both drugs should be reduced or discontinued.
9 Grapefruit juice inhibits liver drug metabolism enzyme P450 and increases the blood drug concentration of this product, which may enhance the action of this drug.

Storage:
Store in dark, closed, room temperature (10-30ºC).