| Customization: | Available |
|---|---|
| Dosage Form: | Infusion |
| Transport Package: | Carton |
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| Generic Name | Sodium Bicarbonate Injection 12.5g/250ml |
| Strength | 12.5g/250ml |
| Packing | 1bottle/box |
| Origin | China |
1. Treat metabolic acidosis. To treat mild to moderate metabolic acidosis, oral administration is appropriate. Severe metabolic acidosis should be given intravenically, such as severe kidney disease, circulatory failure, cardiopulmonary resuscitation, cardiopulmonary bypass, severe primary lactic acidosis, diabetic ketoacidosis, etc.
2. Alkalize urine. It is used to prevent uric acid kidney stones, reduce renal toxicity of sulfonamides, and prevent hemoglobin deposition in renal tubules after acute hemolysis.
3. As an acid-making drug, it treats the symptoms caused by excessive stomach acid.
4. Intravenous infusion has a non-specific therapeutic effect on some drug poisoning, such as barbiturates, salicylic acids and methanol poisoning. However, this product is prohibited for gastric lavage when swallowing strong acid poisoning, because this product reacts with strong acid to produce a large amount of carbon dioxide, resulting in acute gastric dilation or even gastric rupture.
Metabolic acidosis, intravenous infusion, the required dose is calculated as follows: alkali supplement (mmol) = (-2.3- actual measured BE value) ×0.25× body weight (kg), or alkali supplement (mmol) = normal CO2CP- actual measured CO2CP (mmol) ×0.25× body weight (kg). Unless the bicarbonate is lost in the body, 1/3 to 1/2 of the calculated dose is generally given first within 4 to 8 hours. During cardiopulmonary resuscitation, the dosage should be 1mmol/kg for the first time, and then adjusted according to the results of blood gas analysis (each 1g of sodium bicarbonate is equivalent to 12mmol bicarbonate). The following issues should also be noted for intravenous use: (1) The concentration range of intravenous use is 1.5% (isotonic) to 8.4%; (2) should start from a small dose, according to the blood pH value, bicarbonate concentration changes to determine the additional dose; (3) A large amount of intravenous infusion in a short period can cause severe alkalosis, hypokalemia and hypocalcemia. When the dosage of hypertonic solution exceeds 10ml per minute, it can lead to hypernatremia, decreased cerebrospinal fluid pressure and even intracranial hemorrhage, which is more likely to occur in newborns and children under 2 years of age. Therefore, when transfused with 5% solution, the rate should not exceed 8 mmol sodium per minute. However, due to fatal acidosis during cardiopulmonary resuscitation, rapid intravenous infusion should be given. Alkalized urine, adults: 4g orally for the first time, 1-2g every 4 hours thereafter. Intravenous infusion, 2 to 5mmol/kg, 4 to 8 hours to complete the infusion. Children: Oral, daily according to body weight 1-10mmol/kg.
1. Arrhythmia, muscle spasm, pain, abnormal fatigue and weakness may occur during large amounts of intravenous injection, mainly due to hypokalemia caused by metabolic alkalosis.
2. When the dose is too large or there is renal insufficiency, edema, mental symptoms, muscle pain or convulsions, slow breathing, odor in the mouth, abnormal fatigue and weakness may occur. It is mainly caused by metabolic alkalosis.
3. Long-term application can cause frequent urination, urgent urination, persistent headache, loss of appetite, nausea and vomiting, abnormal fatigue and weakness.
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