Valsartan and Amlodipine Tablets 80mg/5mg / High Quality

• Customization: Available
• Certified: GMP
• Dossier: Ctd
• Model NO.: Tablet
• Packing: Customization
• Package: 14 Tablets /Box
• Transport Package: Box
• Specification: 80mg/5mg
• Trademark: Sinolead
• Origin: China
• Production Capacity: 10, 000, 000

Product Description

Valsartan and Amlodipine Tablets 80mg/5mg

Composition:

Each tablet contains:

• Valsartan 80mg
• Amlodipine (as Amlodipine Besylate) 5mg

Description:

This fixed-dose combination contains Valsartan, an angiotensin II receptor blocker (ARB), and Amlodipine, a calcium channel blocker (CCB). Together, they help lower high blood pressure (hypertension) by relaxing blood vessels and improving blood flow.

Indications:

Valsartan and Amlodipine Tablets are indicated for:

• Hypertension (high blood pressure) in patients who require combination therapy
• Reduction of cardiovascular risk in patients with high blood pressure and additional risk factors

Dosage & Administration:

Adults:

• Usual starting dose: 1 tablet (80mg/5mg) once daily
• Dose adjustment: Based on blood pressure response
• Maximum dose: 320mg/10mg per day
• Can be taken with or without food

Pediatric Use:

• Not recommended for children under 18 years due to insufficient safety data.

Renal Impairment:

• No dose adjustment required for mild-to-moderate impairment.
• Severe renal impairment (eGFR <30 mL/min/1.73m²): Use with caution.

Hepatic Impairment:

• Use with caution in patients with mild to moderate liver disease.
• Severe hepatic impairment: Not recommended.

Contraindications:

• Hypersensitivity to Valsartan, Amlodipine, or excipients
• Pregnancy and breastfeeding (Category D - risk to fetus)
• Severe liver disease
• Severe hypotension (low blood pressure)
• History of angioedema with ARBs

Precautions:

• Hypotension: Risk in volume-depleted patients; correct dehydration before starting.
• Kidney Function: Monitor renal function in patients with kidney disease.
• Hyperkalemia: Caution in patients taking potassium supplements or potassium-sparing diuretics.
• Heart Failure: Use with caution in patients with congestive heart failure.

Adverse Reactions:

• Common: Dizziness, headache, fatigue, peripheral edema, flushing
• Gastrointestinal: Nausea, abdominal pain
• Cardiovascular: Hypotension, palpitations
• Musculoskeletal: Muscle cramps, back pain
• Serious (rare): Angioedema, severe hypotension, kidney dysfunction

Drug Interactions:

• NSAIDs: May reduce antihypertensive effect and worsen kidney function.
• Potassium-sparing diuretics (e.g., spironolactone): Risk of hyperkalemia.
• Lithium: Risk of lithium toxicity.
• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): May increase Amlodipine levels.
• Other antihypertensives: May enhance blood pressure-lowering effects.

Storage Conditions:

• Store below 25°C, in a dry place, away from light.
• Keep out of reach of children.