Rocuronium Bromide Injection 5ml: 50mg / High Quality

• Customization: Available
• Packaging From: 5 Ampoules/Box
• Packaging: Customization
• Model NO.: injection
• Dosage: Ready
• Transport Package: Shipping
• Specification: 2ml: 50mg
• Trademark: brand
• Origin: China

Product Description

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Rocuronium Bromide Injection 50mg/5mL

Composition:

Each 5mL vial contains:

• Rocuronium Bromide - 50 mg (10 mg/mL)
• Excipients: Sodium acetate, Sodium chloride, Acetic acid (for pH adjustment), Water for injection

Description:

Rocuronium Bromide is a non-depolarizing neuromuscular blocking agent that competitively inhibits acetylcholine at the neuromuscular junction, resulting in skeletal muscle relaxation and paralysis. It has a rapid onset and intermediate duration of action and is used during surgical procedures and mechanical ventilation.

Indications:

Rocuronium Bromide Injection is indicated for:

• Facilitation of tracheal intubation during general anesthesia
• Maintenance of neuromuscular blockade during surgery
• Use in intensive care units (ICU) for mechanical ventilation

Dosage & Administration:

Adults & Pediatrics (>1 month old)

The dose depends on the desired level of neuromuscular blockade:

Use	Dose	Onset Time	Duration
Intubation (standard dose)	0.6 mg/kg IV	1-2 min	30-40 min
Rapid Sequence Intubation (RSI)	1.0-1.2 mg/kg IV	45-60 sec	50-70 min
Maintenance dose	0.1-0.2 mg/kg IV	-	15-25 min
Continuous infusion	5-10 mcg/kg/min	-	-

Pediatric Considerations:

• Neonates (<1 month): Limited data; use with caution
• Children (1 month-12 years): Require slightly higher doses due to faster metabolism

Administration:

• Administer as an IV bolus or continuous infusion
• Flush IV line with saline after administration
• Use neuromuscular monitoring to determine the optimal dose

Contraindications:

• Hypersensitivity to Rocuronium or bromide compounds
• Severe anaphylactic reactions to other neuromuscular blockers

Precautions:

• Prolonged paralysis may occur in patients with liver or kidney dysfunction
• Use with caution in patients with myasthenia gravis or neuromuscular diseases
• Ensure airway support is available before administration
• May cause histamine release (use caution in asthmatic patients)

Adverse Reactions:

• Common: Injection site pain, transient hypotension or hypertension, tachycardia
• Serious: Anaphylaxis, bronchospasm, prolonged neuromuscular blockade

Drug Interactions:

• Inhaled anesthetics (e.g., Sevoflurane, Isoflurane): Potentiate neuromuscular blockade
• Aminoglycosides & Polymyxins: Enhance paralysis
• Sugammadex Sodium: Effectively reverses Rocuronium-induced blockade
• Corticosteroids: May prolong neuromuscular blockade

Overdose & Management:

• Symptoms: Prolonged paralysis, respiratory depression
• Treatment:
  • Mechanical ventilation support
  • Reversal with Sugammadex (2-16 mg/kg) or Neostigmine + Atropine

Storage Conditions:

• Store between 2°C - 8°C (Refrigerated)
• Do not freeze
• Once opened, use immediately