| Customization: | Available |
|---|---|
| Dosage Form: | Infusion |
| Transport Package: | Carton |
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| Generic Name | Mannitol Injection |
| Strength | 20%/100ml |
| Packing | 1bottle/box |
| Origin | China |
1. Tissue dehydrating drugs. It is used to treat brain edema caused by various reasons, reduce intracranial pressure, and prevent brain hernia.
2. Reduce intraocular pressure. It can effectively reduce intraocular pressure, and can be used when other intraocular pressure lowering drugs are ineffective or before intraocular surgery.
3. Osmotic diuretics. Used to distinguish oliguria from prerenal factors or acute renal failure. It can also be used to prevent acute tubular necrosis caused by various reasons.
4. As an auxiliary diuretic measure to treat nephrotic syndrome and cirrhosis ascites, especially when accompanied by hypoproteinemia.
5. For certain drug overdose or toxic poisoning (such as barbiturates, lithium, salicylate and bromide, etc.), this drug can promote the excretion of these substances and prevent renal toxicity.
6. As a flushing agent, it is used in transurethral prostatectomy.
7. Preoperative intestinal preparation.
1. Adult dosage:
(1) Diuresis: The usual dosage is 1 ~ 2g/kg according to body weight, generally with 20% solution 250m1 intravenous drip, and adjust the dose to maintain urine volume at 30 ~ 50m1 per hour.
(2) The treatment of cerebral edema, intracranial hypertension and glaucoma: according to the body weight of 0.25 ~ 2g/kg, formulated a concentration of 15% ~ 25% intravenous infusion within 30 ~ 60 minutes. When the patient is debilitated, the dose should be reduced to 0.5g/kg. Renal function was closely followed.
(3) Identification of prerenal oliguria and renal oliguria: according to the body weight of 0.2g/kg, at 20% concentration within 3 to 5 minutes of intravenous infusion, if the urine volume is still less than 30 to 50ml per hour after 2 to 3 hours after the drug, at most try again, if there is still no response should stop the drug. Use with caution or should not be used in patients with cardiac dysfunction or heart failure.
(4) Prevention of acute tubular necrosis: First give 12.5 ~ 25g, intravenous infusion within 10 minutes, if there is no special circumstances, then give 50g, intravenous infusion within 1 hour, if the urine volume can be maintained above 50m1 per hour, you can continue to use 5% solution intravenous drip; If it does not work, stop immediately.
(5) Treatment of drugs and poisons: 50g with 20% solution, adjust the dose to maintain urine volume at 100 ~ 500ml per hour.
(6) Intestinal preparation: 4 ~ 8 hours before surgery, 1000ml of 10% solution was taken orally within 30 minutes.
2. Common dosage for children:
(1) Diuresis: according to body weight 0.25 ~ 2g/kg or according to body surface area 60g/, with 15% ~ 20% solution within 2 ~ 6 hours intravenous infusion.
(2) Treatment of cerebral edema, intracranial hypertension and glaucoma: according to body weight 1 ~ 2g/kg or according to body surface area 30 ~ 60g/, with 15% ~ 20% concentration solution within 30 ~ 60 minutes of intravenous infusion. The dose is reduced to 0.5g/kg when the patient is debilitated.
(3) Identification of prerenal oliguria and renal oliguria: according to the body weight of 0.2g/kg or according to the body surface area of 6g/, at 15% to 25% concentration intravenous infusion for 3 to 5 minutes, if the urine volume does not increase significantly after 2 to 3 hours of medication, it can be used again, if there is still no response, it is no longer used.
(4) Treatment of drugs, poisons: according to the body weight 2g/kg or according to the body surface area of 60g/ with 5% to 10% solution intravenous drip.
1. Except for intestinal preparation, all drugs should be administered intravenously.
2. Mannitol is easy to crystallize when it is cold, so it should be carefully checked before application. If there is crystallization, it can be placed in hot water or forcibly oscillated until the crystallization is completely dissolved before use. When the concentration of mannitol is higher than 15%, an infusion set with a filter should be used.
3. Choose the appropriate concentration according to the condition and avoid the unnecessary use of high concentrations and large doses.
4. The use of low-concentration mannitol and sodium chloride-containing solutions can reduce the chance of excessive dehydration and electrolyte disturbances.
5. When used to treat salicylate or barbiturate poisoning, sodium bicarbonate should be combined to alkalize urine.
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