20% Mannitol Injection USP 100ml / High Quality

• Customization: Available
• Packing: Customization
• Materials: PP
• Model NO.: injection
• Transport Package: Carton
• Specification: 100ml
• Trademark: Sinolead
• Origin: China

Product Description

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20% Mannitol Injection 100ml

Product Overview

20% Mannitol Injection is a sterile, non-pyrogenic solution designed for intravenous administration. It contains 20% w/v of Mannitol, a hyperosmotic diuretic, in a 100ml formulation. Mannitol is widely used to reduce intracranial pressure (ICP), intraocular pressure (IOP), and promote diuresis in various clinical conditions.

Key Features

• Active Ingredient: Mannitol

• Concentration: 20% w/v (20g of Mannitol per 100ml of water)

• Formulation: Clear, colorless solution

• Administration: Intravenous infusion

• Packaging: Single-dose bag or bottle, 100ml per unit

Indications

• Reduction of Intracranial Pressure (ICP): Used to treat cerebral edema and elevated ICP caused by traumatic brain injury, stroke, or brain tumors.

• Reduction of Intraocular Pressure (IOP): Effective in managing acute glaucoma or preoperative preparation for ophthalmic surgery.

• Diuresis: Promotes urine production in cases of acute renal failure or toxin/drug overdose.

• Renal Protection: Used during certain surgical procedures (e.g., cardiopulmonary bypass) to prevent renal damage.

Mechanism of Action

• Osmotic Effect: Mannitol increases the osmolarity of blood plasma, drawing fluid from tissues into the bloodstream, thereby reducing edema and pressure in the brain or eyes.

• Diuretic Effect: Mannitol is filtered by the kidneys but not reabsorbed, increasing urine output and promoting the excretion of toxins, drugs, and excess fluid.

Dosage and Administration

• Recommended Dosage:

  • Adults:

    • Cerebral Edema/ICP Reduction: 0.25-2g/kg (25-200ml of 20% solution) infused over 30-60 minutes.

    • Acute Glaucoma/IOP Reduction: 1.5-2g/kg (75-100ml of 20% solution) infused over 30-60 minutes.

    • Diuresis/Renal Protection: 50-100g (250-500ml of 20% solution) infused as needed.

  • Children: Dosage adjusted based on body weight (typically 0.25-1g/kg).

• Administration:

  • Must be administered as a slow intravenous infusion using a filter to prevent crystallization.

  • Monitor vital signs, fluid balance, and electrolyte levels during infusion.

• Compatibility: Compatible with most intravenous fluids, but avoid mixing with other medications.

Advantages

• Rapid Action: Provides quick reduction of intracranial and intraocular pressure.

• Versatile Use: Effective for cerebral edema, acute glaucoma, and diuresis.

• Well-Tolerated: Generally safe when administered correctly.

Storage and Handling

• Storage: Store at controlled room temperature (15-30°C). Protect from freezing and excessive heat.

• Shelf Life: Typically 24-36 months, depending on the manufacturer.

Precautions

• Contraindicated in patients with:

  • Severe renal impairment (anuria).

  • Pulmonary edema or congestive heart failure.

  • Known hypersensitivity to mannitol.

• Use with caution in patients with:

  • Mild to moderate renal impairment.

  • Electrolyte imbalances (e.g., hyponatremia, hyperkalemia).

• Monitor for signs of fluid overload, electrolyte disturbances, or renal dysfunction during treatment.

Adverse Effects

• Common side effects include:

  • Fluid and electrolyte imbalances (e.g., dehydration, hyponatremia).

  • Headache, nausea, or vomiting.

• Rare but serious side effects may include:

  • Acute renal failure (with excessive use).

  • Pulmonary edema or heart failure (with fluid overload).

  • Allergic reactions (e.g., rash, anaphylaxis).