Piroxicam Capsules USP 20mg
Composition:
Each capsule contains:
Description:
Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, and antipyretic properties. It works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the production of prostaglandins, which are responsible for pain, inflammation, and fever.
Indications:
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Musculoskeletal disorders
- Postoperative and traumatic pain relief
Dosage & Administration:
For Oral Use Only.
Adults:
- 20mg once daily OR
- 10mg twice daily (if better tolerated in divided doses)
Special Populations:
- Elderly patients: Use with caution, start with a lower dose if necessary
- Patients with hepatic or renal impairment: Adjust dose under medical supervision
Administration:
- Take with food or milk to minimize gastrointestinal discomfort
- Swallow whole with a full glass of water
- Avoid alcohol while taking this medication
Contraindications:
- Known hypersensitivity to Piroxicam or other NSAIDs
- History of NSAID-induced gastrointestinal bleeding or perforation
- Active peptic ulcer disease
- Severe hepatic or renal impairment
- Third trimester of pregnancy
Warnings & Precautions:
- Increased risk of cardiovascular events (e.g., heart attack, stroke) with long-term use
- May cause gastrointestinal bleeding, ulceration, or perforation
- Avoid in patients with severe hypertension or heart failure
- Use caution in patients with asthma or a history of allergic reactions to NSAIDs
Adverse Reactions:
- Common: Nausea, dyspepsia, abdominal pain, headache
- Serious: Gastrointestinal bleeding, peptic ulcers, hypertension, kidney dysfunction
Drug Interactions:
- Increased risk of bleeding with anticoagulants (e.g., warfarin)
- May reduce the effectiveness of antihypertensive drugs (e.g., ACE inhibitors)
- Increased risk of nephrotoxicity with diuretics or aminoglycosides
- Should not be used with other NSAIDs to avoid toxicity
Storage Conditions:
- Store below 25°C (77°F)
- Protect from moisture and direct sunlight
- Keep out of reach of children




