| Dosage Form: | Infusion |
|---|---|
| Transport Package: | Carton |
| Specification: | 400mg/250ml |
| Trademark: | Sinolead |
| Origin: | China |
| Samples: |
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| Customization: |
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| Generic Name | Moxifloxacin Hydrochloride And Sodium Chloride Injection 400mg/250ml |
| Strength | 400mg/250ml |
| Packing | 1bottle/box |
| Origin | China |
Adults (≥18 years old) with upper and lower respiratory tract infections, such as acute sinusitis, acute episodes of chronic bronchitis, community-acquired pneumonia; And skin and soft tissue infections.
Complex abdominal infections include mixed bacterial infections, such as abscesses.
Usage and dosage:
Dose range (adult) :
The recommended dose is 0.4g once a day (1 bottle at a time, once a day).
Course of treatment:
The course of treatment is determined by the severity of symptoms or clinical response. The treatment of upper and lower respiratory tract infections is usually followed by the following courses:
Acute onset of chronic bronchitis: 5 days
Community acquired pneumonia: Sequential administration (oral administration followed by intravenous administration) is recommended for a total course of treatment of 7 to 14 days.
Acute sinusitis: 7 days
The recommended course of treatment for skin and soft tissue infections is seven days.
Moxifloxacin can be administered intravenously at the beginning of treatment and then orally as a tablet depending on the patient.
The 0.4g moxifloxacin injection was used for a maximum of 14 days in clinical trials.
Administration method:
Intravenous administration of 0.4g should last 90 minutes.
Moxifloxacin can be administered either alone or in combination with a compatible solution.
The following combinations of moxifloxacin and moxifloxacin are considered acceptable for combined administration because they remain stable at room temperature for more than 24 hours:
Water for injection
0.9% sodium chloride injection
1 mole sodium chloride injection
5% glucose injection
10% glucose inj
40% glucose inj
20% xylitol injection
Ringer's fluid
Lactate Ringer's solution
Aminofusin10%(Manufacturer: Pharmacia&Upjohn)
Jonosteril D5 (Fresenius Kabi)
If moxifloxacin injection should be used in combination with other drugs, each drug should be administered separately (see incompatibility).
Only clear solutions should be used.
Moxifloxacin can prolong the QT interval of the ECG in some patients. The drug should be avoided in patients with prolonged QT interval, patients with uncorrected hypokalemia, and patients receiving Class Ia (e.g., quinidine, procayamide) or Class III (e.g., amiodarone, sotalolol) antiarrhythmic medications.
Moxifloxacin and drugs that may prolong the QT interval: cisaprik, erythromycin, antipsychotics, and tricyclic antidepressants, may have an additive effect when taken in combination. Therefore, these drugs should be used with caution.
Moxifloxacin should be used with caution in the presence of arrhythmogenic conditions, such as severe bradycardia or acute myocardial ischemia.
Because women tend to have a longer QTc interval than men, they may be more sensitive to drugs that trigger a prolonged QTc interval. Older patients are also more likely to suffer from drug-induced prolonged QT intervals.
Pregnant women: The safety of moxifloxacin use in humans during pregnancy has not been established. Quinolones can cause reversible joint damage in children, but this effect has not been reported in fetuses of pregnant users. Animal studies have shown reproductive toxicity with moxifloxacin, but the potential risk to humans is unclear. Therefore, moxifloxacin is contraindicated in women during pregnancy.
Lactating women: As with other quinolones, moxifloxacin can cause cartilage damage in weight-bearing joints in juvenile test animals. Preclinical studies have confirmed that small amounts of moxifloxacin can be distributed to human milk, but data for lactating women are lacking. Therefore, moxifloxacin is contraindicated in lactating women.
Drug interaction:
Antacids, minerals, and multivitamins: Moxifloxacin taken with antacids, minerals, and multivitamins reduces drug absorption due to the formation of polyvalent chelates with polyvalent cations in these substances. This will result in a lower concentration of the drug in the plasma than expected, so antacids, antiretrovirals (such as deoxyinosine), other preparations containing magnesium or aluminum, aluminum thiolate, and minerals containing iron or zinc need to be taken at least 4 hours before or 2 hours after oral moxifloxacin.
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