GMP Certified / Medroxyprogesterone Acetate Injectable Suspension

• Quality Standard: USP, Bp
• Factory Certified: GMP
• Ctd Status: Available
• Transport Package: Sea Transportation
• Specification: 150mg/1.5ml
• Trademark: Sinolead
• Model NO.: injection
• Origin: China
• Production Capacity: 100, 000, 000 Per Year

Product Description

Product Description
 

Generic name	Medroxyprogesterone Acetate Injectable Suspension
Strength	150mg/1.5ml
Standard	BP
Shelf life	5 Years
Packing form	1 vial/box

Value-added services:
 Packaging design by our team
 Registration service by our team
 Registration dossier available by our team
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Product name:
Medroxyprogesterone Acetate Injectable Suspension

Character:
This product is a suspension of fine particles. After standing, the fine particles sink and form a uniform milky white suspension after shaking.

Indications:
Medroxyprogesterone acetate injection, indication is 1. Contraception 2. Treatment of endometriosis 3. Treatment of menopausal vasomotor symptom4. As palliative care for recurrent and/or metastatic endometrial or renal cancer 5. Treatment of postmenopausal hormone-dependent and/or recurrent breast cancer Contraception/endometriosis: Since bone mineral density can be reduced in premenopausal women with long-term use of medroprogesterone acetate inj, the risk/benefit of bone mineral density loss during pregnancy and/or lactation should be evaluated.

Pharmacology and toxicology:
Medroxyprogesterone acetate is a progesterone derivative.
Action mechanism
Medroxyprogesterone acetate is a synthetic progesterone (similar in structure to the endogenous hormone progesterone) that has been shown to have several pharmacological effects on the endocrine system:
· Inhibit pituitary(FSH and LH);
· Decreased blood concentrations of ACTH;
· Decrease circulating;
· Decrease of circulating estrogen levels (resulting from increased clearance due to FSH inhibition and induction of liver reductase enzymes, thereby reducing androgen to estrogen conversion)
All these effects lead to many pharmacological effects, as described below.
[u] Contraception [/u]
When administered parenterally in women at recommended doses, medroxyprogesterone acetate inhibits secretion, which prevents follicle maturation and ovulation, and leads to thinning of the endometrium.
[u] Gynecology [/u]
Medroxyprogesterone acetate converts hyperplastic to secretory membranes when given orally or by parenteral routes at recommended doses in women with sufficient endogenous estrogen. Androgen and anabolic effects have been found, but the drug clearly lacks significant estrogenic activity. Although parenteral administration of medroxyprogesterone acetate inhibits production and thus prevents follicle maturation and ovulation, available data suggest that this effect does not occur when the commonly recommended oral dose is used as a single daily dose.
[u] Endometriosis [/u]
The inhibition of serum estradiol concentration and the possible direct effect of medroxyprogesterone acetate subcutaneous administration on endometriosis lesions may be related to the therapeutic efficacy of endometriosis related pain.
[u] tumor [/u]
Medroxyprogesterone acetate has antitumor activity. Medroxyprogesterone acetate injection is effective in palliative care of hormone-sensitive malignancies when administered at high doses.
Carcinogenesis, mutagenesis, reproductive damage
It has been shown that long-term intramuscular administration of medroxyprogesterone acetate can cause breast tumors in beagles. There is no evidence that oral medroxyprogesterone acetate has carcinogenic effects in rats and mice when administered orally. Medroxyprogesterone acetate has no mutagenic effect in a set of in vitro or in vivo genotoxicity tests. Medroxyprogesterone acetate is an antireproductive drug at high doses, which can affect reproductive ability until treatment is stopped.

Storage:
Storage at controlled room temperature (15ºC-30ºC)