Spironolactone Tablets 25mg / High Quality

• Customization: Available
• Packaging From: 100 Tablets /Bottle; 30tablets/Box
• Packaging: Customization
• Model NO.: Tablet
• Dosage: Ready
• Transport Package: Shipping
• Specification: 25mg
• Trademark: Customization
• Origin: China

Product Description

Value-added services:
 1) Packaging design by our team
 2) Registration service by our team
 3) Registration dossier available by our team
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Spironolactone Tablets 25mg

Composition:

Each tablet contains:

• Spironolactone 25mg

Description:

Spironolactone is a potassium-sparing diuretic that works by blocking aldosterone, a hormone that regulates salt and water balance. It is used to treat high blood pressure, heart failure, and conditions associated with excessive aldosterone production.

Indications:

Spironolactone Tablets are indicated for:

• Edema due to congestive heart failure, liver cirrhosis, or nephrotic syndrome
• Hypertension (high blood pressure)
• Primary hyperaldosteronism (Conn's syndrome)
• Hypokalemia (low potassium levels)
• Heart failure (NYHA Class III-IV) to reduce morbidity and mortality

Dosage & Administration:

Adults:

• Edema & Hypertension: 25-100mg once daily, adjusted as needed
• Severe Heart Failure: 25mg once daily, up to 50mg/day if tolerated
• Primary Hyperaldosteronism: 100-400mg daily (before surgery or long-term treatment)
• Hypokalemia: 25-100mg daily

Pediatric Use:

• Edema & Hypertension: 1-3mg/kg/day in divided doses

Renal Impairment:

• Use with caution in mild to moderate kidney disease
• Contraindicated in severe renal impairment (eGFR <30 mL/min/1.73m²)

Hepatic Impairment:

• Use with caution in liver disease, as fluid-electrolyte balance is critical

Administration:

• Take once daily, preferably in the morning
• Can be taken with or without food
• Do not crush or chew

Contraindications:

• Hypersensitivity to Spironolactone or excipients
• Severe kidney disease or anuria
• Hyperkalemia (high potassium levels)
• Addison's disease (adrenal insufficiency)
• Concomitant use with potassium supplements or potassium-sparing diuretics

Precautions:

• Monitor potassium levels regularly (risk of hyperkalemia)
• Caution in diabetic patients (higher risk of hyperkalemia)
• Risk of gynecomastia (breast enlargement in men) with long-term use
• Use with caution in elderly patients due to increased risk of electrolyte imbalance
• May cause dizziness-avoid driving or operating machinery

Adverse Reactions:

• Common: Dizziness, headache, nausea, menstrual irregularities
• Electrolyte Imbalance: Hyperkalemia, hyponatremia
• Hormonal Effects: Gynecomastia, breast tenderness, irregular menstruation
• Serious (rare): Severe hyperkalemia, kidney dysfunction, metabolic acidosis

Drug Interactions:

• ACE inhibitors & ARBs: Increased risk of hyperkalemia
• NSAIDs: May reduce diuretic effect and worsen kidney function
• Lithium: Increased risk of lithium toxicity
• Digoxin: May increase digoxin toxicity risk
• Other diuretics: Increased dehydration and electrolyte disturbances

Storage Conditions:

• Store below 25°C, in a dry place, away from light.
• Keep out of reach of children.