| Generic Name |
Doxycycline Capsules BP |
| Strength |
100mg |
| Packing |
10*10 Capsules/box |
| Origin |
China |
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Product name:
Doxycycline Capsules BP 100mg
Character:
This product is a capsule, the content is white or white crystalline powder.
Indications:
1. As one of the selected drugs, this product can be used for the following diseases: (1) Rickettsial diseases, such as epidemic typhus, endemic typhus, Rocky Mountain fever, chigger disease and Q fever. (2) Mycoplasma infection. (3) Chlamydia infections, including psittacosis, venereal diseases, lymphosarcodontia, non-specific urethritis, salpingitis, cervicitis and trachoma. (4) Relapsing fever. (5) Brucellosis. (6) Cholera. (7) Tularemia. (8) Plague. (9) Soft chancre.
2. Treatment of brucellosis and plague should be combined with aminoglycosides.
3. Due to the serious resistance of common pathogens to tetracycline, only when the pathogenic bacteria are sensitive to this product, there is an indication of application. Most staphylococci are resistant to this product.
4. This product can be used in patients allergic to penicillins for tetanus, gas gangrene, yaws, syphilis, gonorrhea and leptospirosis, as well as actinomyces and listeria infections.
5. It can be used as an adjunct therapy for patients with moderate and severe acne.
Adverse reactions:
1. Digestive system: Oral administration of this product can cause nausea, vomiting, abdominal pain, diarrhea and other gastrointestinal reactions. Esophagitis and esophageal ulcers have occasionally been reported, mostly in patients who became bedridden immediately after taking medication.
2. Hepatotoxicity: Fatty liver degeneration occurs easily in patients and pregnant women, and can also occur in patients without the above conditions. Pancreatitis may occasionally occur, and pancreatitis caused by this product may also occur simultaneously with hepatotoxicity, and the patient does not have primary liver disease.
3. Allergic reaction: mostly maculopapules and erythema, a few patients can have urticaria, angioneuroedema, anaphylactoid purpura, pericarditis and systemic lupus erythematosus skin lesions aggravated, exfoliative dermatitis is not common. Occasionally, anaphylactic shock and asthma occur. Some patients with this product may have photosensitivity to the sun. Therefore, it is recommended that patients should not be directly exposed to sunlight or ultraviolet rays during the use of this product, and should immediately stop taking the drug once the skin has erythema.
4. Blood system: Occasionally causes hemolytic anemia, thrombocytopenia, neutropenia, and eosinophil penia.
5. Central nervous system: Occasionally can cause benign intracranial pressure increase, can be manifested as headache, vomiting, optic nerve papilledema, etc., can be relieved after withdrawal.
6. Double infection: Long-term use of this product can occur resistant staphylococcus aureus, gram-negative bacteria and fungi caused by digestive tract, respiratory tract and urinary tract infections, severe cases can cause sepsis.
Seven. The application of tetracycline can reduce the normal flora in the human body, and cause vitamin deficiency, fungal reproduction, dry mouth, pharyngitis, Angle of mouth and tongue inflammation.
Pharmacology and toxicology:
Tetracycline antibiotics This product is a broad spectrum bacteriostatic agent, high concentration has bactericidal effect. Many Rickettsiella, Mycoplasma, Chlamydia, atypical Mycobacterium and spirochaeta are also sensitive to this product. The action of this product against gram-positive bacteria is better than gram-negative bacteria, but enterococcus is resistant to it. Others such as actinomyces, anthrax, Listeria monocytogenes, Clostridium, Nocardia, Vibrio, Brucella, Campylobacter, Yersinia are sensitive to this product. This product has certain antibacterial activity against Neisseria gonorrhoeae, but penicillin-resistant Neisseria gonorrhoeae is also resistant to doxycycline. Due to the extensive application of tetracycline over the years, the common clinical pathogens are seriously resistant to this product, including gram-positive bacteria such as staphylococcus and most gram-negative bacteria. There is cross-resistance between this product and different varieties of tetracycline antibiotics. The mechanism of action of this product is that the drug can specifically bind to the A position of 30S subunit of bacterial ribosome, inhibit the growth of peptide chain and affect the synthesis of bacterial protein. Animal tests confirmed that this product has teratogenicity. The in vitro test shows that this product has the possibility of mutagenicity at certain concentration.
Storage:
Seal and store in a dry place.
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