| Generic Name |
Rifampicin Capsules |
| Strength |
300mg |
| Packing |
10*10 Capsules/box |
| Origin |
China |
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Product name:
Rifampicin Capsules 300mg
Character:
This product is a capsule containing bright red or dark red crystalline powder.
Indications:
1. This product is used in combination with other anti-tuberculosis drugs for the initial and retreatment of various tuberculosis, including the treatment of tuberculous meningitis.
2. This product is used in combination with other drugs for the treatment of leprosy and non-tuberculosis mycobacterium infection.
3. This product and vancomycin (intravenous) can be used in combination for serious infections caused by methicillin-resistant staphylococcus. The combination regimen of rifampicin and erythromycin is used for severe Legionella infections.
4. For asymptomatic Neisseria meningitidis carriers to eliminate Neisseria meningitidis nasopharynx; It is not suitable for the treatment of Neisseria meningitidis infection.
Adverse reactions:
1. Gastrointestinal reactions: The most common, after oral administration of this product can appear anorexia, nausea, vomiting, upper abdominal discomfort, diarrhea and other gastrointestinal reactions, the incidence of 1.7% ~ 4.0%, but can be tolerated.
2. Hepatotoxicity is the main adverse reaction of this product, with an incidence of about 1%. In the first few weeks of treatment, a small number of patients may develop elevated serum aminotransferase, liver enlargement and jaundice, mostly asymptomatic transient elevated serum aminotransferase, which can be recovered during the course of treatment. Elderly people, alcoholics, malnutrition, pre-existing liver disease or other factors caused by abnormal liver function are more likely to occur.
3. Allergic reactions: "influenza-like symptoms" may occasionally appear after high-dose intermittent therapy, including chills, chills, fever, discomfort, dyspnea, dizziness, lethargy and muscle pain, etc. The frequency of occurrence is significantly related to the dose size and interval time. Occasionally acute hemolysis or renal failure may occur, and the mechanism is currently considered to be anaphylaxis.
4. Others: After taking this product, urine, urine, saliva, sputum, tears, etc., can be orange. Occasionally, leukopenia, shortened prothrombin time, headache, vertigo, visual impairment, etc.
Pharmacology and toxicology:
Rifampicin is a semi-synthetic broad-spectrum rifamycin antibiotic, which has antibacterial activity against many pathogenic microorganisms. The drug has obvious bactericidal effect on M. tuberculosis and some non-M. tuberculosis (including M. leprae, etc.) both inside and outside the host cell. Rifampicin has a good antibacterial effect on aerobic gram-positive bacteria, including staphylococcus enzyme producing strains and methicillin-resistant strains, Streptococcus pneumoniae, other streptococcus genera, Enterococcus genera, Listeria genera, anthrax bacillus, perfringens bacillus, diphtheria bacillus, anaerobic coccus, etc. It also has high antibacterial activity against aerobic gram-negative bacteria such as Neisseria meningitidis, Haemophilus influenzae and Neisseria gonorrhoea.
Rifampin also has a good effect on Legionella, and has an inhibitory effect on chlamydia trachomatis, venereal lymphogranuloma and pectin fever. Bacteria are cross-resistant to rifamycin antibiotics. Rifampicin binds firmly to the beta subunit of DNA-dependent RNA polymerase, inhibiting the synthesis of bacterial RNA and preventing the enzyme from linking to DNA, thus blocking the RNA transcription process and stopping the synthesis of DNA and proteins.
Storage:
Seal and store in a dark (no more than 20 ° C) dry place.
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